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Clinical Research

Low-Dose Naltrexone and Met-Enkephalin Improve EAE Mice

Naltrexone
Widely touted in multiple sclerosis patient communities, low-dose naltrexone does appear to improve disease scores in about half of mice with an experimentally induced version of MS. Researchers found a similar pattern of results with met-enkephalin.
A growing subculture of MS patients and clinicians has been touting low-dose...
Clinical Research, Drug Development, Laboratory Research, Meetings

Kir4.1 Potassium Channels in MS: Discrepant Results From Two Studies

Birth of an idea
Two teams of researchers found strikingly different degrees of autoimmune response to Kir4.1 inward rectifying potassium channels among multiple sclerosis patients. At first, the reason for the discrepancy wasn’t obvious.
When experimental findings disagree, or demonstrate very different strengths of an association, several explanations are...
Clinical Research, Laboratory Research

Few MS Patients Fail to Receive Disease-Modifying Therapy

Neurologist survey
A survey of neurologists showed that most patients with MS received DMT; that patient satisfaction and adherence were best with fingolimod; but that insurance coverage for fingolimod was worse than for self-injectable DMTs
According to a survey of neurologists published online April 3 in Patient Preference and Adherence, the vast majority of patients with multiple sclerosis received...
Clinical Research

Make Way for Another MS Model?

Mouse models comparison
In a head-to-head comparison of four MS models, one based on HSV-1 infection shows its value
It’s caused plenty of embarrassment, but the virus that triggers cold sores could also provide insight into...
Clinical Research, Drug Development, Laboratory Research, Meetings, Methods, People

Decoding Brain Disease

Orion wanted poster
Computer analyses extract new insights from MS patient data
Since he was diagnosed with multiple sclerosis in 2007, Curtis Schreiner, a three-time U.S. Olympian in the biathlon, has...
Clinical Research, Drug Development, Laboratory Research, Meetings, Methods, People

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