The Design of MRI-Related Clinical Trials in MS

Developed by Khawai.

Understanding and analyzing the design of past clinical trials is a key factor in planning future trials.

This visualization details the design of 88 clinical trials with magnetic resonance imaging (MRI) reports published between 1993 and 2014. It makes it easy to see which of five key measurements were reported in each trial and when during the course of that trial those measurements were made.

The measurements are:

• Expanded Disability Status Scale (EDSS)
• Gadolinium-enhancing lesion (GdEnh Lesion)
• T2-hyperintense lesion volume (Volume T2)
• Brain Volume
• Combined Active Lesion (CAL)

The top chart combines information from all the trials in each of the four phases. The size of each circle is a function of the number of trials reporting this measurement. Switching between phases will allow you to visualize the differences in the frequency and the type of data available.

The bottom chart displays information on individual trials. Select a trial with the drop-down menu to update the chart.

Data source: click here to download the database (csv format)