Clinical Research

Clinical Risk Calculator for MS: How Close Are We?

Decoding MS risk factors is less like fitting together a jigsaw puzzle and more like balancing a Jenga tower, with layer upon layer of complex interactions and unpredictable outcomes if something changes

When we need it, we have the Framingham risk assessment tool to determine our risk for...

Clinical Research

Tracking Remyelination: Do You See What I See?

Several new imaging modalities are aimed at evaluating possible remyelination in patients with multiple sclerosis. This article discusses how the techniques work and their potential applications to MS, as well as their limitations.

For nearly 15 years, magnetic resonance imaging has been an important tool for...

Clinical Research

Incomplete B-Cell Depletion Linked to Fewer MRI Lesions

In a dose-ranging study of the anti-CD20 antibody ofatumumab, even incomplete depletion of peripheral B cells was associated with a reduced number of MRI brain lesions in patients with RRMS

When treating relapsing-remitting multiple sclerosis patients with anti-B cell antibodies, complete depletion of B cells is...

Clinical Research, Drug Development, Meetings

Can Gut Microbes Provide Answers About MS?

Is the gut as interesting as the brain? Researchers probing the ecosystem of the human gut microbiome have identified organisms that are enriched or depleted in MS patients, possibly yielding clues about pathogenic mechanisms. Meanwhile, introducing a nonhuman pathogen into the gut is being investigated as a possible treatment approach.

“I am going to argue that the gut is as interesting as the brain,” said...

Clinical Research

MS Research Roundup: May 27, 2014

Sex, Drugs, and Preclinical Research; Promising Biomarker for Progressive MS; Journalist With MS Finds Hope in Stem Cell Trial

Items of interest to multiple sclerosis researchers from around the Web...

Clinical Research, Drug Development, Laboratory Research, People

Oral Contraceptive Use Linked to Less Severe Relapsing-Remitting MS

Women with RRMS who use combined oral contraceptives tend to have less severe disease, although the retrospective study could not establish causation

Combined oral contraceptive use is associated with a less severe...

Clinical Research

MS Research Roundup: May 20, 2014

Pregnancy Hormone May Augment MS Treatment; Happy International Clinical Trials Day; Online Comment Provokes Evidence Milestone; Hanging Ten With Floppy Feet

Items of interest to multiple sclerosis researchers from around the Web...

Clinical Research, Drug Development, People

Genetic Marker May Underlie Sex Difference in MS Susceptibility

Females susceptible to MS produce higher levels of a blood vessel receptor protein, S1PR2, than males, suggesting the possibility of a new therapeutic target

In mouse models and in humans, females susceptible to multiple sclerosis produce higher levels of...

Clinical Research, Laboratory Research

MS Research Roundup: May 16, 2014

Stem Cells Help Mice Walk; Cooling the Immune Response

Items of interest to multiple sclerosis researchers from around the Web...

Clinical Research, Laboratory Research

AAN Review Supports Treating Symptoms of MS with Cannabis

A review of the literature conducted by the American Academy of Neurology supports the use of cannabis to treat some symptoms of MS, including spasticity, pain related to spasticity, overactive bladder, and painful burning and numbness

A review of available scientific research presented at the AAN Annual Meeting found that certain forms of cannabis can...

Clinical Research

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Clinical Risk Calculator for MS: How Close Are We?

Tracking Remyelination: Do You See What I See?

Incomplete B-Cell Depletion Linked to Fewer MRI Lesions

Can Gut Microbes Provide Answers About MS?

MS Research Roundup: May 27, 2014

Oral Contraceptive Use Linked to Less Severe Relapsing-Remitting MS

MS Research Roundup: May 20, 2014

Genetic Marker May Underlie Sex Difference in MS Susceptibility

MS Research Roundup: May 16, 2014

AAN Review Supports Treating Symptoms of MS with Cannabis

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