Novel Remyelination AssayOligodendrocytes wrap around glass micropillars, allowing high-throughput assays of potential remyelination agents.
Innate Differences in Demyelination
Axon Transport Deficits
Myelin and Axons Don’t Form a Uniform Union
Welcome to the Multiple Sclerosis Discovery Forum
A variant of a gene called SLC9A9 appears significantly more often in people with MS who fail to respond to interferon β therapy
About 20% of patients do not meet the diagnostic criteria of clinically isolated syndrome (CIS) based on radiological and clinical evidence. Patients who do not fit the CIS diagnostic criteria may yet have oligoclonal bands distinct to CSF, increased IgG synthesis rate and IgG index and must be treated as if they carried a diagnosis of CIS.
An animal model that presents an alternative to EAE suggested a role for sodium channel blockers in neuroprotection. This led directly to a successful human trial of phenytoin, which was presented at last week’s AAN meeting.
We surveyed our readers, and you gave us a few surprises
Every Friday, MSDF editors use a curated PubMed search to link to every newly published MS-related paper. Here’s how we do it.
Tools that will help investigators conceive and perform experimental work:
The Data Visualization section presents MS-related data in new ways, making it easy for viewers to discover unexpected relationships
Our latest data visualization presents a set of word clouds that allow you see the most common terms used in scientific studies describing multiple sclerosis clinical trials.
- Drug-Development Pipeline consolidates key information about compounds under investigation for therapeutic use
We've recently added 13 new trials, updated information on 28 trials, and added 74 other pieces of information. The drugs with important additions and changes are alemtuzumab, BAF312, BIIB033, daclizumab, dalfampridine, dimethyl fumarate, fingolimod, glatiramer acetate, interferon β-1a, interferon β-1b, laquinimod, mitoxantrone, naltrexone, natalizumab, phenytoin, rituximab, RPC1063, and teriflunomide.
- Tissue Repositories lists features of the world's tissue repositories and brain banks, including rules of engagement and contact information
- MSGene provides a comprehensive, unbiased and regularly updated collection of genetic association studies performed on multiple sclerosis phenotypes
- Clinical Trials lists sources of information about MS clinical trials
Meetings and Events catalogs future and past meetings of interest to the MS-research community
- Funding Opportunities provides information about where to obtain grants
- Jobs offers descriptions of available positions
Member Directory displays profiles of MS-research community members
Bulletin Board allows MSDF members to post notices
Useful Links lists helpful resources elsewhere on the web
Amyloid has potent anti-inflammatory abilities which may explain what it is trying to do in Alzhe
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