Myelin and Axons Don’t Form a Uniform Union
Rare Family MS Cluster Reveals New Clues
Stem Cells Stop the Train of MS Damage in Mice
Early B Cells Found In Gut, Schooled By Microbes
Welcome to the Multiple Sclerosis Discovery Forum
Progress Toward New MS Clinical Trial Outcomes; Adaptive Design Evolves; A Call for Fundamental Neuroscience Research; MS Miracle Cures
Lenaldekar blocks inflammation, demyelination, and axon degeneration in a mouse model of MS
New findings from mice may rewrite our understanding of just about everything myelin-related. Outside experts describe the study as “landmark,” “novel,” “unexpected,” “new,” “important,” “surprising,” “stunning,” and “provocative.”
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Regarding the Heartbleed Bug: Pantheon, our web host, patched their platform on Monday, April 7,
In a randomized trial, access to antibody testing affected MS management. Serum binding antibodies predicted positivity to neutralizing antibodies in patients on high-dose interferon.
The unphosphorylated, “inactive” version of fingolimod may be responsible for one of the drug’s most serious downsides: susceptibility to viral infections
Tools that will help investigators conceive and perform experimental work:
- Drug-Development Pipeline consolidates key information about compounds under investigation for therapeutic use
We've recently added five new trials, updated information on three other trials, and added 27 other pieces of information. The drugs with important additions and changes are alemtuzumab, dimethyl fumarate, fingolimod, glatiramer acetate, interferon β-1a, interferon β-1b, and natalizumab.
We've also added GNbAC1 as a new entry, which contains information on two trials and 16 other pieces of information.
- Tissue Repositories lists features of the world's tissue repositories and brain banks, including rules of engagement and contact information
- MSGene provides a comprehensive, unbiased and regularly updated collection of genetic association studies performed on multiple sclerosis phenotypes
Animal Models summarizes the promises and pitfalls of animal models used in MS research
- Clinical Trials lists sources of information about MS clinical trials
Meetings and Events catalogs future and past meetings of interest to the MS-research community
- Funding Opportunities provides information about where to obtain grants
- Jobs offers descriptions of available positions
Member Directory displays profiles of MS-research community members
Bulletin Board allows MSDF members to post notices
Useful Links lists helpful resources elsewhere on the web
Most Popular Content
- Who We Are
- More Than Meets the Eye
- Harnessing Epitope Spreading to Treat MS
- Explaining Fingolimod’s Fatal Flaw
- Transdermal Myelin Peptides May Be Safe, Effective in MS
- Small Internal Jugular Veins Linked to Severe MS
- Beyond Reasonable Doubt: The vitamin D piece of the MS puzzle
- Old Drug May Wield New Power
- MS Research Roundup: March 31, 2014
- The Many Faces of B Cells
- The Oligodendrocyte Whisperer
- Genomic Double Play
- More Signal Abnormalities Seen in Relatives of MS Patients
- Phase 1 Trial of Stem Cells Begins in MS
- New Pathogen Linked to MS
- Rare Family Cluster of MS Reveals New Clues
- Stem Cells Enhanced to Generate Myelin-Producing Cells
- Single Calcitriol Dose Beats Back EAE in Mice
- Nature, Nurture, and What’s in Between
- MS Cognitive Impairment Rates Lower Than Previously Reported
- Early B Cells Found in Gut, Schooled by Microbes
- Corticosteroids Ineffective for Many With Relapsing MS
- Serum Vitamin D Levels Predict Severity of MS
- Vitamin D3 Blocks T Helper Cells From Entering the CNS
- Is Normal Pressure Hydrocephalus A Component of Multiple Sclerosis Pathology?
- Remyelination: Are Exosomes Containing microRNA the Answer?
- First-Attack Multiple Sclerosis Targets Gray Matter
- Easy Cognitive Assessments for People With MS
- MS Research Roundup: April 8, 2014
- MS-SMART Trial for Secondary Progressive MS Announced
- Abnormal Venous Outflow Dynamics May Not Be Implicated in MS
- Venocentric Lesions on MRI: An Early Marker of MS?
- Genetic Associations
- Benign MS Expresses Itself
- MS Patient, Ph.D.
- Plasma Osteopontin Levels: A New Marker for MS?
- Sleep Boosts Remyelinating Glial Cells
- Anti-Inflammatory Apolipoprotein May Protect Against MS Symptoms
- FDA's Denial of Alemtuzumab Stirs Controversy
- Myelin and Axons Don’t Form a Perfect, Uniform Union
- Survey Finds “MSer” to Be Patients' Preferred Descriptor
- Cheap Vaccine Slows MS Progression
- Type 1 Diabetes Linked to Higher MS Risk Among Youth
- Cortical MS Lesions Linked to “Normal” White Matter Injury
- Early-Detection Probe for MS Exploits Coagulation Protein
- Cognitive Reserve in MS: Life Experiences Matter
- Antigen-Specific Therapy for MS Passes Safety Test
- NMDA Receptors May Modulate Severity of Multiple Sclerosis
- Transcutaneous Electrical Nerve Stimulation Shows Promise in MS
- Anti-EBV Serology, HLA-DR Risk Profiles May Help Identify MS
- Gut Bacteria Boost Anti-Inflammatory Immune Cells in Mice
- PUMA Protein May Underlie Oligodendroglial Cell Death in MS
- Toso: A New Drug Target for MS?
- Tears Yield Possible MS Biomarker
- Autologous Stem Cell Transplant Effective in Inflammatory RRMS; Mechanism Emerging
- MS Patient, Ph.D.: MS and Vitamin D: What’s a Patient to Do?
- High Noon at the Th17 Corral
- Cannabinoid Receptor Variant Linked to MS Neurodegeneration
- MS Research Roundup: January 15, 2014
- MS Patient, Ph.D.: Greetings From Limbo Land
- CCSVI Not Linked to MS in Large Study
- Sex Differences in MS Are Genetic, Not Just Hormonal
- Update: Risk Factors
- National MS Society Partners With Accelerated Cure Project Online Forum to Drive Progress
- A New MS Journal
- New NARCOMS Analysis Focuses on Symptom-Specific Impairment
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- Immune Attack: Primary or Secondary?
- How should we refer to someone with MS?
- Biomarkers: Foretelling the Future
- Total Brain Sodium on MRI Linked to More Severe MS
- Natalizumab Emerges on Top in Network Meta-Analysis
- Video Game Revs Up Brain Power
- Sexual Dysfunction Fuels Mental Problems in MS Patients
- Oral Laquinimod May Reduce Destructive Pathology in RRMS
- B Cells Step Into the Limelight
- Ebb and Flow of EBV
- Neuromyelitis Optica, Part 2: Pathogenesis
- MS Research Roundup: February 7, 2014
- Neuromyelitis Optica, Part 1: The Other Disease
- Obstructive Sleep Apnea Contributes to MS Fatigue
- DMDs Are an Essential Issue But Are They the Only Issue in MS Treatment?
- Oral Cannabinoid Dronabinol Doesn’t Modify Disease in Progressive MS
- Debate: Do Physicians Rate the Risk of Disabling MS Less Than the Risk of Effective Treatment?
- Fatigue in MS Linked to Elevated Body Temperature
- Study Reveals New Facets of NMO Pathophysiology
- New Mouse Model of Progressive MS Sheds Light on Aggressive Disease
- Gate Crashers
- Altered Immunity, Crippled Neurons
- Multiple sclerosis susceptibility genes: associations with relapse severity and recovery.
- The fraction of varicella zoster virus-specific antibodies among all intrathecally-produced antibodies discriminates between patients with varicella zoster virus reactivation and multiple sclerosis.
- Genome-wide Study Brings MS Landscape Into Sharper Focus
- Low Vitamin D May Not Be Linked to Epstein-Barr Virus Status
- Neurofilament-tubulin binding site peptide NFL-TBS.40-63 increases the differentiation of oligodendrocytes in vitro and partially prevents them from lysophosphatidyl choline toxiciy.