Innate Differences in Demyelination
Axon Transport Deficits
Myelin and Axons Don’t Form a Uniform Union
Novel Remyelination AssayOligodendrocytes wrap around glass micropillars, allowing high-throughput assays of potential remyelination agents.
Welcome to the Multiple Sclerosis Discovery Forum
A variant of a gene called SLC9A9 appears significantly more often in people with MS who fail to respond to interferon β therapy
About 20% of patients do not meet the diagnostic criteria of clinically isolated syndrome (CIS) based on radiological and clinical evidence. Patients who do not fit the CIS diagnostic criteria may yet have oligoclonal bands distinct to CSF, increased IgG synthesis rate and IgG index and must be treated as if they carried a diagnosis of CIS.
An animal model that presents an alternative to EAE suggested a role for sodium channel blockers in neuroprotection. This led directly to a successful human trial of phenytoin, which was presented at last week’s AAN meeting.
We surveyed our readers, and you gave us a few surprises
Every Friday, MSDF editors use a curated PubMed search to link to every newly published MS-related paper. Here’s how we do it.
Tools that will help investigators conceive and perform experimental work:
The Data Visualization section presents MS-related data in new ways, making it easy for viewers to discover unexpected relationships
Our latest data visualization presents an interactive timeline of the key milestones in the development of the 12 currently available treatments in MS.
- Drug-Development Pipeline consolidates key information about compounds under investigation for therapeutic use
We've recently added six new trials, updated information on six trials, and added 55 other pieces of information. The drugs with important additions and changes are alemtuzumab, ATX-MS-1467, BIIB033, dalfampridine, dimethyl fumarate, dronabinol, fingolimod, glatiramer acetate, imilecleucel-T, interferon β-1a, interferon β-1b, mycophenolate mofetil, natalizumab, rituximab, and RPC1063.
- Tissue Repositories lists features of the world's tissue repositories and brain banks, including rules of engagement and contact information
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Meetings and Events catalogs future and past meetings of interest to the MS-research community
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Amyloid has potent anti-inflammatory abilities which may explain what it is trying to do in Alzhe
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