RRMS and CIS—Baseline Characteristics
Developed by Khawai.
Clinical trials can sometimes be hard to compare because the patients enrolled in those trials start out with different characteristics. This data visualization clearly reveals those differences. We analyzed 74 MS clinical trials reported between 1993 and 2014, and we extracted mean values of the 5 most frequently reported characteristics: age, gender, Expanded Disability Status Scale (EDSS) score, number of gadolinium enhancing lesions (GdEnh), and volume of T2 lesions (VolT2) in cm3. We then displayed those characteristics on radar plots.
The two large radar plots at the top represent the overall means, weighed for the number of people in each trial, for relapsing remitting MS (RRMS) and clinically isolated syndrome (CIS). On each axis you may mouse over the dot to display the corresponding value.
The smaller plots represent the values for the 74 individual trials, arranged in reverse order by publication date. Green radars present trials run in CIS populations and blue ones in RRMS populations (or with a majority of RRMS patients). You’ll notice that in some of the trials some of the characteristics were not reported. If you mouse over the individual trials you’ll find some of the trial details, including the number of patients in the trial and the name of the study’s first author.
If you click on an individual trial, that trial’s data will be overlaid on the large radar plots, allowing you easily to see how that trial’s baseline characteristics differ from the mean.
Data source: click here to download the database (Excel format)