Clinical Trials - Public Availability of Results
Developed by Khawai.
"A key principle in the good conduct of clinical trials is that a summary of the trial protocol should be freely available while the study is ongoing and that, on completion of the study, the results should be readily accessible to all in a timely fashion (within one year of completion of the trial)." (Prayle, AP, Hurley MN, Smyth AR. "Compliance with mandatory reporting of clinical trial results on ClinicalTrials.gov: cross sectional study.” BMJ. 2012 Jan 3;344:d7373.)
This data visualization shows what portion of clinical trials in multiple sclerosis have made their results publicly available on clinicaltrials.gov.
- Click on a tab to separate the listed trials by various parameters.
- Hover over a bubble to learn more about that trial.
- Click on a bubble for more information on that trial as reported by clinicaltrials.gov.
"At present, clinical trials of drugs that already have FDA approval are required to report results within one year of completion of the trial (with some provisions for delayed reporting). These results are posted in the form of a table of values for each of the pre-specified primary and secondary outcome measures for each arm of the clinical trial, with associated statistical tests." (Prayle, AP, Hurley MN, Smyth AR. "Compliance with mandatory reporting of clinical trial results on ClinicalTrials.gov: cross sectional study.” BMJ. 2012 Jan 3;344:d7373.)
We obtained clinical trial data from ClinicalTrials.gov through March 2017.
- Clinical trials in MS completed before March 2016
The types of interventions were extracted fromClinicalTrials.gov
The sponsor categories were created by Khawai based on information extracted from FiercePharma .
Note: Not all studies or types of studies are required to post on ClinicalTrials.gov . Please also note that some studies that haven’t posted their results on ClinicalTrials.gov may have made them available elsewhere.
A bubble chart typically displays data triplets (x, y, z) corresponding to three continuous variables: x and y to define the position, and z, the radius of each bubble. In our example, x and y coordinates are optimized according to an algorithm which essentially balances bubble's gravity (i.e. action of moving towards the center of the plot), friction (i.e. velocity decay), and charge (or repulsion/attraction force). This layout is frequently used for network visualization. In addition to x, y and z, it is possible to encode other information. For instance, the color coding informs us about the availability of the results for each trial, while each tab provides a different view of what the trials breakdown looks like. So, the current webpage displays data from 550 clinical trials, in 6 different ways.