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Refined Animal Model Led to Phenytoin Clinical Trial

Katie Lidster
In 2010, Professor David Baker was awarded an NC3Rs Project Grant to develop a...
An animal model that presents an alternative to EAE suggested a role for sodium channel blockers in neuroprotection. This led directly to a successful human trial of phenytoin, which was presented at last week’s AAN meeting.
Clinical Research, Drug Development, Laboratory Research, Meetings, Methods

Seeking Answers for Progressive MS

International Progressive MS Alliance logo
An invitational meeting in Boston marks a step forward in a concerted international push to find effective therapies to target disease mechanisms, manage symptoms, and improve rehabilitation
A meeting in Boston early in March drew more than 80 scientists and clinical researchers to address...
Clinical Research, Drug Development, Laboratory Research, Meetings

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Clinical Research, Drug Development, Laboratory Research, Meetings, Methods, People

Low CD8+ T Cell Counts Found With Dimethyl Fumarate

Dimethyl fumarate
A recent study found that patients taking dimethyl fumarate (Tecfidera) had low counts of CD8+ T cells, though their overall levels of lymphocytes were within the normal range. The findings suggest that physicians may want to monitor specific lymphocyte levels in addition to doing full blood cell counts.
In November 2014, Biogen Idec confirmed its first case of progressive multifocal leukoencephalopathy, a rare brain infection, in...
Clinical Research


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