Clinical Research

Lessons From Fingolimod for Primary Progressive Multiple Sclerosis

Fingolimod is ineffective for PPMS, but the phase 3 trial data may improve future studies

Even in failure, studies can be informative. Fingolimod, a disease-modifying treatment for relapsing-remitting multiple sclerosis, is...

Clinical Research, Drug Development, Meetings, Methods, People

Taking Studies of Sex Differences to the Next Level

It is now over a year since the announcement of a new National Institutes of Health policy to encourage...

Multiple sclerosis affects about three times more women than men, but pregnancy can protect against relapses, and MS in men tends to worsen faster. These naturally occurring sex differences could lead to new treatments—if they don’t stall on the way to the clinic.

Clinical Research, Drug Development, Laboratory Research

Will Death in French Drug Trial Lead to Tighter Phase 1 Rules?

While regulators are trying to figure out what went wrong, independent chemists have dug into the mechanism of what may have been a "dirty" drug

January saw one of the worst drug trial debacles in memory, when a healthy volunteer participating...

Clinical Research, Drug Development, Laboratory Research

Podcasts discuss new MS treatment strategy

The MS Brain Health collection

No cure yet exists for MS, but a new therapeutic strategy may help extend brain health, delay progressive disease, and reduce future disability. That’s the assertion of a new report released at the October 2015 ECTRIMS meeting in Barcelona.

Clinical Research, Meetings

Episode 67 with Neda Razaz on children of parents with MS

Young children of parents with MS seem to develop normally to age 5, with the possible exception of a parent with a co-morbid mental health condition. This area of research aims to identify any areas where interventions could help support children and their families.

Clinical Research, Methods

MS Research Roundup: 8 January 2016

Mind-Body Evidence in MS; Your MS Research Playlist; This Bike Has MS & Kiss Goodbye to MS

Items of interest to multiple sclerosis researchers from around the Web...

Clinical Research, People

Probing T Cell Gene Regulatory Networks for Early Signs of Disease

A network model of gene expression during human T cell differentiation, combined with results of genome-wide association studies, helps identify potential disease markers in asymptomatic patients with MS

In relapsing-remitting multiple sclerosis, normally protective immune T cells transform into effector cells that...

Clinical Research, Laboratory Research

PodBlog: B-Cell Double Header

In episodes 56 and 57 of the MS Discovery podcast, Gavin Giovannoni, MBBCH, PhD, and Timothy Vollmer, MD, discuss the first large-scale study of a drug showing some benefits in a progressive form of multiple sclerosis. The story goes back decades, as Stephen Hauser, MD, recently explained.

A former beauty queen made a big impression on Stephen Hauser, MD, when he was...

Clinical Research, Drug Development, Laboratory Research, Meetings, People

MS Research Roundup: October 16, 2015

Highlights from the 2015 meeting of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) in Barcelona: B-Cell Bashing Ocrelizumab; New Outcome Measure for Daclizumab

Items of interest in multiple sclerosis research from around the Web...

Clinical Research, Drug Development, Meetings

PodBlog: Status of Stem Cell Therapies for MS

Episode 55 of the MSDF podcast features Michael Levy, MD, PhD, of Johns Hopkins University School of Medicine, who discusses the status of regenerative stem cell therapies for multiple sclerosis.

Episode 55 of the MSDF podcast is out. Check it out. The podcast features an interview with...

Clinical Research, Drug Development, Laboratory Research, Meetings, People

Multiple Sclerosis Discovery Forum

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