Clinical Research

Low Vitamin D May Not Be Linked to Epstein-Barr Virus Status

Low 25(OH)D3 did not affect EBV load or anti-EBV nuclear antigen-1 titer in a young, healthy cohort

Low 25-hydroxyvitamin D3 levels did not affect Epstein-Barr virus load or anti-EBV nuclear antigen-1 titer in a...

Clinical Research

Ultrahigh-Field MRI May Detect Additional Pathology in EAE

In a mouse model of MS, ultrahigh-field MRI detected lesions not visible with conventional MRI. The technique also detected signs of spinal cord ischemia in human patients with MS.

Ultrahigh-field magnetic resonance imaging may detect pathological changes not visible with conventional MRI, according to...

Clinical Research, Laboratory Research

Teriflunomide, Interferon β-1a Show Comparable Efficacy

A phase 3 head-to-head study found no difference in annualized relapse rate between teriflunomide 14 mg and interferon β-1a

Teriflunomide can be considered a reasonable alternative to interferon β-1a in treating patients with relapsing forms of multiple sclerosis...

Clinical Research

MS Susceptibility Gene Variants Linked to Clinical Features

MS susceptibility gene variants are linked to relapse severity, recovery, and early attack location

Genetic polymorphisms associated with MS may be useful markers to include in prognostic models...

Clinical Research

Neuromyelitis Optica, Part 4: Unresolved Questions

And finally, a look at some unresolved questions, such as people diagnosed with NMO who don’t have the aquaporin antibody, and the funding situation

A recent study that compared several antibody assays found that about a quarter of patients diagnosed with NMO lack...

Clinical Research, Drug Development, Laboratory Research, People

Neuromyelitis Optica, Part 3: Treatment and Prevention

After discussing NMO pathogenesis, we’ll talk about current treatments, as well as efforts to find better treatments and even prevent NMO attacks

Because NMO patients essentially suffer from inflammation, doctors first try to stop an acute NMO attack with...

Clinical Research, Drug Development, Laboratory Research, People

Neuromyelitis Optica, Part 2: Pathogenesis

Now that we’ve seen how researchers came to the conclusion that NMO differs from MS, let’s take a closer look at the current understanding of its pathogenesis

About three-quarters of NMO patients have the aquaporin-4 antibody, a number that has been steadily...

Clinical Research, Drug Development, Laboratory Research, People

Neuromyelitis Optica, Part 1: The Other Disease

Once thought of as a variant of multiple sclerosis, neuromyelitis optica is now clearly understood to be a different disease

Lea Long still remembers the moment her life changed like it was yesterday. She was in the...

Clinical Research, Drug Development, Laboratory Research, People

CCSVI Not Linked to MS in Large Study

In CoSMo, the prevalence of CCSVI did not differ in MS, other neurological diseases, or healthy controls

The prevalence of chronic cerebrospinal venous insufficiency in multiple sclerosis did not differ from that in...

Clinical Research

Oral Laquinimod May Reduce Destructive Pathology in RRMS

Laquinimod appears to reduce brain MRI findings of inflammatory destruction in relapsing-remitting multiple sclerosis

Treatment with oral laquinimod may reduce MRI evidence of destructive brain pathology in...

Clinical Research, Drug Development

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Low Vitamin D May Not Be Linked to Epstein-Barr Virus Status

Ultrahigh-Field MRI May Detect Additional Pathology in EAE

Teriflunomide, Interferon β-1a Show Comparable Efficacy

MS Susceptibility Gene Variants Linked to Clinical Features

Neuromyelitis Optica, Part 4: Unresolved Questions

Neuromyelitis Optica, Part 3: Treatment and Prevention

Neuromyelitis Optica, Part 2: Pathogenesis

Neuromyelitis Optica, Part 1: The Other Disease

CCSVI Not Linked to MS in Large Study

Oral Laquinimod May Reduce Destructive Pathology in RRMS

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