Multiple Sclerosis Discovery Forum

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Clinical efficacy of BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the DEFINE study.
The quality of reports of randomized trials in multiple sclerosis: a review.
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination.
Comparative effectiveness of fingolimod versus interferons or glatiramer acetate for relapse rates in multiple sclerosis: a retrospective US claims database analysis.
MS Research Roundup: An Introduction
Teva announces U.S. FDA approval of three-times-a-week COPAXONE® (glatiramer acetate injection) 40mg/mL
ForuMS: A Virtual Journal Club for MS Clinicians
Request for Applications for Collaborative Network Awards from the Progressive MS Alliance
Assessment and Imaging of the Cerebrovascular Glycocalyx.
Primary results of DECIDE: a randomized, double-blind, double-dummy, active-controlled trial of daclizumab HYP vs. Interferon β-1a in RRMS patients
Optical coherence tomography should be part of the routine monitoring of patients with multiple sclerosis: Yes.
Management of worsening multiple sclerosis with mitoxantrone: a review.
The cost of multiple sclerosis drugs in the US and the pharmaceutical industry: too big to fail?
Therapeutic effects of systemic administration of chaperone αB-crystallin associated with binding proinflammatory plasma proteins.
Clinical Trials
Comparison of Switch to Fingolimod or Interferon Beta/Glatiramer Acetate in Active Multiple Sclerosis.
MS clinical trials: what can subgroup analyses teach us?
Cost Effectiveness of Fingolimod, Teriflunomide, Dimethyl Fumarate and Intramuscular Interferon-β1a in Relapsing-Remitting Multiple Sclerosis.
Biogen Idec to acquire Fumapharm AG; Consolidates ownership of oral compound BG-12 being studied for multiple sclerosis
Masitinib in the treatment of active rheumatoid arthritis: results of a multicentre, open-label, dose-ranging, phase 2a study.
Long-term impact of interferon beta-1b in patients with CIS: 8-year follow-up of BENEFIT.
Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor kcyB (NF-kcyB) and Extracellular Signal-regulated kinase 1 and 2 (ERK1/2) and Mitogen Stress activated kinase 1 (MSK1) signaling.
17 beta-estradiol inhibits cytokine, chemokine, and chemokine receptor mRNA expression in the central nervous system of female mice with experimental autoimmune encephalomyelitis.
Correlation between anti-interferon-β binding and neutralizing antibodies in interferon-β-treated multiple sclerosis patients.
Siponimod (BAF312) for the Treatment of Secondary Progressive Multiple Sclerosis: Design of the Phase 3 EXPAND Trial

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