Drug Development

Episode 81 with Dr. Kaarina Kowalec

Still in early days in MS, pharmacogenomics may have the potential optimize the risk/benefit profile in a patient's favor, focusing first on the risk of liver injury with interferon-beta.

Clinical Research, Drug Development

Episode 80 with Dr. Kaarina Kowalec on adverse MS drug reactions

Approximately 1 in 50 people with MS in British Columbia, Canada, developed drug-induced liver injury with about three months of exposure to interferon-beta IFN-β. The study of adverse drug reactions will help minimize or prevent the toxicity of MS drugs, a major clinical objective.

Clinical Research, Drug Development

Episode 71 with Dr. Brian Weinshenker on innovative clinical trials for NMO

MSDF interviews Brian Weinshenker MD of the Mayo Clinic about innovative ways to do clinical trials involving neuromyelitis optica, now considered a separate disease from MS.

Clinical Research, Drug Development

The MSDF Drug-Development Pipeline

The founder and curator of MSDF’s drug database reveals how it keeps you up to date with experimental and approved therapies in MS and related demyelinating diseases

Dozens of new MS drug-related developments are published in scientific papers or described in...

Clinical Research, Drug Development

MS Research Roundup: 27 February 2016

FDA Fast-Tracks PPMS Drug Review; Molecular Target Runs Out of Air; Happy Accidents in the Lab; New Twist on Patient-Powered Research

Items of interest to multiple sclerosis researchers from around the Web...

Clinical Research, Drug Development, Laboratory Research, Meetings, People

Lessons From Fingolimod for Primary Progressive Multiple Sclerosis

Fingolimod is ineffective for PPMS, but the phase 3 trial data may improve future studies

Even in failure, studies can be informative. Fingolimod, a disease-modifying treatment for relapsing-remitting multiple sclerosis, is...

Clinical Research, Drug Development, Meetings, Methods, People

Taking Studies of Sex Differences to the Next Level

It is now over a year since the announcement of a new National Institutes of Health policy to encourage...

Multiple sclerosis affects about three times more women than men, but pregnancy can protect against relapses, and MS in men tends to worsen faster. These naturally occurring sex differences could lead to new treatments—if they don’t stall on the way to the clinic.

Clinical Research, Drug Development, Laboratory Research

Will Death in French Drug Trial Lead to Tighter Phase 1 Rules?

While regulators are trying to figure out what went wrong, independent chemists have dug into the mechanism of what may have been a "dirty" drug

January saw one of the worst drug trial debacles in memory, when a healthy volunteer participating...

Clinical Research, Drug Development, Laboratory Research

MS Research Roundup: November 25, 2015

MS: A Family Story; Take Your Brain Outside; Thank You, MS Researchers

Items of interest to multiple sclerosis researchers from around the Web...

Drug Development, People

PodBlog: B-Cell Double Header

In episodes 56 and 57 of the MS Discovery podcast, Gavin Giovannoni, MBBCH, PhD, and Timothy Vollmer, MD, discuss the first large-scale study of a drug showing some benefits in a progressive form of multiple sclerosis. The story goes back decades, as Stephen Hauser, MD, recently explained.

A former beauty queen made a big impression on Stephen Hauser, MD, when he was...

Clinical Research, Drug Development, Laboratory Research, Meetings, People

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Episode 81 with Dr. Kaarina Kowalec

Episode 80 with Dr. Kaarina Kowalec on adverse MS drug reactions

Episode 71 with Dr. Brian Weinshenker on innovative clinical trials for NMO

The MSDF Drug-Development Pipeline

MS Research Roundup: 27 February 2016

Lessons From Fingolimod for Primary Progressive Multiple Sclerosis

Taking Studies of Sex Differences to the Next Level

Will Death in French Drug Trial Lead to Tighter Phase 1 Rules?

MS Research Roundup: November 25, 2015

PodBlog: B-Cell Double Header

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