FDA approval of Isentress (raltegravir) US Food and Drug Administration, 25 Jun 2009 Accessed on 17 Dec 2013 from http://www.fda.gov/ForConsumers/ByAudience/ForPatientAdvocates/HIVandAIDSActivities/ucm124040.htm.
Raltegravir (Isentress) pilot study in relapsing multiple sclerosis (INSPIRE) ClinicalTrials.gov, 12 Jul 2013 Accessed on 17 Dec 2013 from http://www.clinicaltrials.gov/ct2/show/NCT01767701.
ChemIDplus Advanced United States National Library of Medicine Accessed on 29 Jul 2013 from http://chem.sis.nlm.nih.gov/chemidplus/chemidheavy.jsp. Note: Compound name must be entered under "Substance Identification" and then "Names and Synonyms" selected to view synonyms.
Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals. Markowitz M, Morales-Ramirez JO, Nguyen B-Y, Kovacs CM, Steigbigel RT, Cooper DA, Liporace R, Schwartz R, Isaacs R, Gilde LR, et al. J Acquir Immune Defic Syndr. 2006 Dec 15; 43(5):509-15. PMID: 17133211. Abstract
Autoimmune disease: A role for new anti-viral therapies? Dreyfus DH Autoimmun Rev. 2011 Dec; 11(2):88-97. Epub 2011 Aug 18. PMID: 21871974. Abstract
Raltegravir with optimized background therapy for resistant HIV-1 infection. Steigbigel RT, Cooper DA, Kumar PN, Eron JE, Schechter M, Markowitz M, Loutfy MR, Lennox JL, Gatell JM, Rockstroh JK, et al. N Engl J Med. 2008 Jul 24; 359(4):339-54. PMID: 18650512. Abstract
Efficacy and safety of raltegravir for treatment of HIV for 5 years in the BENCHMRK studies: final results of two randomised, placebo-controlled trials. Eron JJ, Cooper DA, Steigbigel RT, Clotet B, Gatell JM, Kumar PN, Rockstroh JK, Schechter M, Markowitz M, Yeni P, et al. Lancet Infect Dis. 2013 Jul; 13(7):587-96. Epub 2013 May 07. PMID: 23664333. Abstract
Pharmacology of HIV integrase inhibitors. Adams JL, Greener BN, Kashuba ADM Curr Opin HIV AIDS. 2012 Sep; 7(5):390-400. PMID: 22789987. Abstract
ISENTRESS® prescribing information Merck Sharp & Dohme Corp., 2013 Accessed on 9 Jan 2014 from http://www.merck.com/product/usa/pi_circulars/i/isentress/isentress_pi.pdf.
Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme. Kassahun K, McIntosh I, Cui D, Hreniuk D, Merschman S, Lasseter K, Azrolan N, Iwamoto M, Wagner JA, Wenning LA Drug Metab Dispos. 2007 Sep; 35(9):1657-63. Epub 2007 Jun 25. PMID: 17591678. Abstract
Biochemical and antiviral activity of MK-0518, a potent HIV integrase inhibitor Miller M, Witmer M, Stillmock K, Felock P, Ecto L, Flynn J, Schleif W, Dornadula G, Danovich R, Hazuda D, Oral abstract session: AIDS 2006 - XVI International AIDS Conference, 13-18 Aug 2006: Abstract no. THAA0302 Accessed on 9 Jan 2014 from http://www.iasociety.org/Default.aspx?pageId=11&abstractId=2191670.
Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain. Nadal M, Mas PJ, Mas PJ, Blanco AG, Arnan C, Solà M, Hart DJ, Coll M Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16078-83. Epub 2010 Aug 30. PMID: 20805464. Abstract
Humoral immune response to EBV in multiple sclerosis is associated with disease activity on MRI. Farrell RA, Antony D, Wall GR, Clark DA, Fisniku L, Swanton J, Khaleeli Z, Schmierer K, Miller DH, Giovannoni G Neurology. 2009 Jul 7; 73(1):32-8. Epub 2009 May 20. PMID: 19458321. Abstract
Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease. Perron H, Germi R, Bernard C, Garcia-Montojo M, Deluen C, Farinelli L, Faucard R, Veas F, Stefas I, Fabriek BO, et al. Mult Scler. 2012 Dec; 18(12):1721-36. Epub 2012 Mar 28. PMID: 22457345. Abstract
HERVs in neuropathogenesis. Christensen T J Neuroimmune Pharmacol. 2010 Sep; 5(3):326-35. Epub 2010 Apr 27. PMID: 20422298. Abstract
Resolution of autoimmune thrombocytopenia associated with raltegravir use in an HIV-positive patient. Gentile I, Bonadies G, Buonomo A R, Minei G, Borrelli F, Foggia M, Chiurazzi F, Borgia G Platelets. 2013; 24(7):574-7. Epub 2012 Nov 06. PMID: 23130846. Abstract