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Laboratory Research

New Myelin Required to Learn a New Task

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Researchers have discovered that oligodendrocytes play an active role in learning motor tasks. Rodents whose oligodendrocyte precursor cells were blocked from maturation were unable to acquire a novel motor skill.
When neuroscientists talk about the process of learning, they usually discuss...
Laboratory Research

Some Astrocytes Appear to Promote Progressive MS

LacCer
Researchers have identified a key enzyme in astrocytes that turns on during the progressive stage of multiple sclerosis, apparently boosting the local immune response and promoting neurodegeneration. The team is following up by testing a repurposed drug that targets the enzyme in mice and human cells.
In the brain and spinal cord, neurons are the undisputed heads of state, the...
Laboratory Research

“Long Life” Protein Klotho Powers Remyelination in Mice

Clotho
Klotho is known to play a role in a number of age-related diseases, such as Alzheimer’s. New research suggests that a small molecule that boosts production of this protein may enhance maturation of OPCs into myelin-producing cells.
According to Greek myth, Clotho was the youngest of the three Morai, the trio of fates responsible for...
Laboratory Research, Meetings

MS Research Roundup: October 3, 2014

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Stem Cells Pass Safety Trials; Generic Similar to Copaxone; Epigenetic Differences in Monocytes and Macrophages; One Brain, Many Genomes
Items of interest to multiple sclerosis researchers from around the Web...
Clinical Research, Drug Development, Laboratory Research, Methods

The Paradox of Daclizumab

Dr. Bibiana Bielekova
Phase 3 results show that daclizumab reduces disease activity in relapsing-remitting multiple sclerosis by half compared with interferon, as measured by brain imaging, with skin and other side effects. The drug works in surprising ways that are revealing new details about the pathogenesis of MS.
Three might be the lucky number for daclizumab, an investigational drug for relapsing-remitting multiple sclerosis with...
Clinical Research, Drug Development, Laboratory Research, Meetings

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