UCSF MSDB
Sponsoring organization
University of California, San Francisco (UCSF), Medical Center Multiple Sclerosis Genetics Group
http://www.neurology.ucsf.edu/msdb/index.html
Repository website
http://www.neurology.ucsf.edu/msdb/scientist_resources-temp.html
Primary contact
UCSF Clinical Coordinator
513 Parnassus Avenue Room S-256 Box 0435
San Francisco, CA 94143-0435
Tel (toll-free in the U.S.)
1-866-MS-GENES or
1-866-674-3637
Fax 1-415-476-1256
msdb@ucsf.edu
Sample types available
DNA samples from MS patients from single-case families and multicase families and control samples.
Sample-processing information
Not specified.
Data available for each sample
Not specified.
Quantity of available samples
Multicase Families: 96 families, consisting of a total of 598 individuals, 236 affected, and 136 affected sibling pairs.
Single-Case Families: 253 families consisting of a total of 752 individuals. This includes 209 trio families (an affected and 2 parents) and 44 Sib-TDT families (an affected, a sibling, and a parent).
Cases: 447 affected cases are available.
Controls: 210 unrelated controls are available.
Who can request samples
DNA samples are available to qualified researchers studying MS or other diseases that will help researchers understand the underlying causes of MS. Potential users are instructed to request a login and password from msdb@ucsf.edu, providing affiliation information and a brief explanation of the nature of interest in the repository. (NOTE: The biorepository is currently under construction; please email with any questions.)
Cost
Not specified.
How to request samples
Not specified.
Requirements associated with sample use
Not specified.
Ongoing sample collection?
Yes.
Sample publications
Multiple sclerosis susceptibility alleles in African Americans.
Johnson BA, Wang J, Taylor EM, Caillier SJ, Herbert J, Khan OA, Cross AH, De Jager PL, Gourraud PA, Cree BC, Hauser SL, Oksenberg JR.
Genes Immun. 2010 Jun;11(4):343-50. Epub 2009 Oct 29. PMID: 19865102
Refining the association of MHC with multiple sclerosis in African Americans.
McElroy JP, Cree BA, Caillier SJ, Gregersen PK, Herbert J, Khan OA, Freudenberg J, Lee A, Bridges SL Jr, Hauser SL, Oksenberg JR, Gourraud PA.
Hum Mol Genet. 2010 Aug 1;19(15):3080-8. Epub 2010 May 12. PMID: 20466734
Evidence for polygenic susceptibility to multiple sclerosis—the shape of things to come.
International Multiple Sclerosis Genetics Consortium (IMSGC), Bush WS, Sawcer SJ, de Jager PL, Oksenberg JR, McCauley JL, Pericak-Vance MA, Haines JL.
Am J Hum Genet. 2010 Apr 9;86(4):621-5. Epub 2010 Apr 1. PMID: 20362272
Multiple sclerosis pharmacogenomics: maximizing efficacy of therapy.
Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.
International MHC and Autoimmunity Genetics Network, Rioux JD, Goyette P, Vyse TJ, Hammarström L, Fernando MM, Green T, De Jager PL, Foisy S, Wang J, de Bakker PI, Leslie S, McVean G, Padyukov L, Alfredsson L, Annese V, Hafler DA, Pan-Hammarström Q, Matell R, Sawcer SJ, Compston AD, Cree BA, Mirel DB, Daly MJ, Behrens TW, Klareskog L, Gregersen PK, Oksenberg JR, Hauser SL.
Proc Natl Acad Sci U.S.A. 2009 Nov 3;106(44):18680-5. Epub 2009 Oct 21. PMID: 19846760
Longitudinal system-based analysis of transcriptional responses to type I interferons.
Pappas DJ, Coppola G, Gabatto PA, Gao F, Geschwind DH, Oksenberg JR, Baranzini SE.
Physiol Genomics. 2009 Aug 7;38(3):362-71. Epub 2009 Jun 16. PMID: 19531577
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S; International MS Genetics Consortium, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA, Oksenberg JR.
Nat Genet. 2009 Jul;41(7):776-82. Epub 2009 Jun 14. PMID: 19525953
Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis.
Baranzini SE, Srinivasan R, Khankhanian P, Okuda DT, Nelson SJ, Matthews PM, Hauser SL, Oksenberg JR, Pelletier D.
Brain. 2010 Sep;133(9):2603-11. PMID: 20802204
A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.
Cree BA, Rioux JD, McCauley JL, Gourraud PA, Goyette P, McElroy J, De Jager P, Santaniello A, Vyse TJ, Gregersen PK, Mirel D, Hafler DA, Haines JL, Pericak-Vance MA, Compston A, Sawcer SJ, Oksenberg JR, Hauser SL; IMAGEN; IMSGC.
PLoS One. 2010 Jun 25;5(6):e11296. PMID: 20593013
Refining the association of MHC with multiple sclerosis in African Americans.
McElroy JP, Cree BA, Caillier SJ, Gregersen PK, Herbert J, Khan OA, Freudenberg J, Lee A, Bridges SL Jr, Hauser SL, Oksenberg JR, Gourraud PA.
Hum Mol Genet. 2010 Aug 1;19(15):3080-8. Epub 2010 May 12. PMID: 20466734