Substance Name: Amiloride ChemIDplus Advanced, US National Library of Medicine Accessed on 25 Jul 2014 from http://chem.sis.nlm.nih.gov/chemidplus/rn/2609-46-3.
MS-SMART: Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial ClinicalTrials.gov, 24 Jul 2013 Accessed on 25 Jul 2014 from http://clinicaltrials.gov/ct2/show/NCT01910259.
Amiloride Clinical Trial In Optic Neuritis (ACTION) ClinicalTrials.gov, 26 Mar 2013 Accessed on 25 Jul 2014 from http://clinicaltrials.gov/ct2/show/NCT01802489.
Amiloride Hydrochlorothiazide as Treatment of Acute Inflammation of the Optic Nerve ClinicalTrials.gov, 5 May 2014 Accessed on 25 Jul 2014 from http://clinicaltrials.gov/ct2/show/NCT01879527.
Editors' Pick Targeting ASIC1 in primary progressive multiple sclerosis: evidence of neuroprotection with amiloride. Arun T, Tomassini V, Sbardella E, de Ruiter MB, Matthews L, Leite M I, Gelineau-Morel R, Cavey A, Vergo S, Craner M, et al. Brain. 2013 Jan; 136(Pt 1):106-15. Epub 1969 Dec 31. PMID: 23365093. Abstract
Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system. Friese MA, Craner MJ, Etzensperger R, Vergo S, Wemmie JA, Welsh MJ, Vincent A, Fugger L Nat Med. 2007 Dec; 13(12):1483-9. Epub 2007 Nov 11. PMID: 17994101. Abstract
Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model. Vergo S, Craner MJ, Etzensperger R, Attfield K, Friese MA, Newcombe J, Esiri M, Fugger L Brain. 2011 Feb; 134(Pt 2):571-84. Epub 2011 Jan 13. PMID: 21233144. Abstract
Use of amiloride and multiple sclerosis: registry-based cohort studies. Pasternak B, Svanström H, Nielsen NM, Melbye M, Hviid A Pharmacoepidemiol Drug Saf. 2012 May 3. PMID: 22555991. Abstract
Mechanism of action, pharmacokinetics, adverse effects, and therapeutic uses of amiloride hydrochloride, a new potassium-sparing diuretic. Vidt DG Pharmacotherapy. 1981 Nov-Dec; 1(3):179-87. PMID: 6927605. Abstract
Amiloride: a molecular probe of sodium transport in tissues and cells. Benos DJ Am J Physiol. 1982 Mar; 242(3):C131-45. PMID: 7039345. Abstract
Amiloride HCl Par Pharmaceutical, 2010 Accessed on 28 Jul 2014 from http://www.parpharm.com/generics/index.php?option=com_products&product_id=49884011701&Itemid=90.
Amiloride HCI Tablets, USP 5 mg Perrigo Accessed on 28 Jul 2014 from http://www.perrigo.com/business/product.aspx?ID=108&brand=Midamor®.
Generic Midamor eMedTV, 18 Sep 2013 Accessed on 28 Jul 2014 from http://hypertension.emedtv.com/midamor/generic-midamor.html.
SigmaPharm Laboratories Products SigmaPharm Laboratories, 2011 Accessed on 28 Jul 2014 from http://sigmapharm.com/sigmapharm-products.html.
Drug record: Amiloride LiverTox, US National Laboratory of Medicine, 2 Jul 2014 Accessed on 28 Jul 2014 from http://livertox.nih.gov/Amiloride.htm.
Potassium-Retaining Diuretics: Amiloride Palmer LG, Kleyman TR, in Diuretics, R. F. Greger et al. (eds.), Springer-Verlag, 1995 Accessed on 29 Jul 2014 from http://link.springer.com/chapter/10.1007/978-3-642-79565-7_10#page-1.
Product Insert, Amiloride HCl Tablets Perrigo, Mar 2013 Accessed on 30 Jul 2014 from http://www.perrigo.com/files/rx/pdfs/prod108-2202163%20INS%20TOP%20Amiloride%20HCl0312.pdf.
Molecular properties of epithelial, amiloride-blockable Na+ channels. Garty H FASEB J. 1994 May; 8(8):522-8. PMID: 8181670. Abstract
The delta-subunit of the epithelial sodium channel (ENaC) enhances channel activity and alters proteolytic ENaC activation. Haerteis S, Krueger B, Korbmacher C, Rauh R J Biol Chem. 2009 Oct 16; 284(42):29024-40. Epub 2009 Aug 28. PMID: 19717556. Abstract
The mammalian Na+/H+ exchanger gene family--initial structure/function studies. Tse M, Levine S, Yun C, Brant S, Pouyssegur J, Donowitz M J Am Soc Nephrol. 1993 Oct; 4(4):969-75. PMID: 8286718. Abstract
Amiloride Clinical Trial In Optic Neuritis (ACTION) protocol: a randomised, double blind, placebo controlled trial. McKee JB, Elston J, Evangelou N, Gerry S, Fugger L, Kennard C, Kong Y, Palace J, Craner M BMJ Open. 2015; 5(11):e009200. PMID: 26553836. Abstract