Papers: 20 Feb 2015 - 27 Feb 2015 Check out this week's papers from PubMed. If you are a member, please log in to recommend and comment on papers. If you are not a member, please register today and join the conversation. Papers: Editors' Pick The best basic science paper in multiple sclerosis in 2014: Important role for the choroid plexus in the central nervous system entry of leukocytes. Kooij G, de Vries HE Mult Scler. 2015 Feb 25. Epub 1969 Dec 31. PMID: 25716882. Abstract Editors' Pick The outcome spectrum of multiple sclerosis: disability, mortality, and a cluster of predictors from onset. Tedeholm H, Skoog B, Lisovskaja V, Runmarker B, Nerman O, Andersen O J Neurol. 2015 Feb 26. Epub 1969 Dec 31. PMID: 25712541. Abstract Neurodegenerative diseases and therapeutic strategies using iron chelators. Ward RJ, Dexter DT, Crichton RR J Trace Elem Med Biol. 2015 Jan 22. PMID: 25716300. Abstract Neuromyelitis optica spectrum disorder as a paraneoplastic manifestation of lung adenocarcinoma expressing aquaporin-4. Iorio R, Rindi G, Erra C, Damato V, Ferilli M, Sabatelli M Mult Scler. 2015 Feb 25. PMID: 25716881. Abstract Anti-muscarinic adjunct therapy accelerates functional human oligodendrocyte repair. Abiraman K, Pol SU, O'Bara MA, Chen G-D, Khaku ZM, Wang J, Thorn D, Vedia BH, Ekwegbalu EC, Li J-X, et al. J Neurosci. 2015 Feb 25; 35(8):3676-88. PMID: 25716865. Abstract Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome. Disanto G, Adiutori R, Dobson R, Martinelli V, Dalla Costa G, Runia T, Evdoshenko E, Thouvenot E, Trojano M, Norgren N, et al. J Neurol Neurosurg Psychiatry. 2015 Feb 25. PMID: 25716934. Abstract Cost Effectiveness Analysis of Avonex and CinnoVex in Relapsing Remitting MS. Najafi B, Ghaderi H, Jafari M, Najafi S, Ahmad Kiadaliri A Glob J Health Sci. 2015; 7(2):38659. PMID: 25716386. Abstract Patient perspectives on physician conflict of interest in industry-sponsored clinical trials for multiple sclerosis therapeutics. Solomon AJ, Klein EP, Corboy JR, Bernat JL Mult Scler. 2015 Feb 25. PMID: 25716879. Abstract A randomized, controlled, single-blind, 6-month pilot study to evaluate the efficacy of MS-Line!: a cognitive rehabilitation programme for patients with multiple sclerosis. Gich J, Freixanet J, García R, Vilanova J C, Genís D, Silva Y, Montalban X, Ramió-Torrentà L Mult Scler. 2015 Feb 25. PMID: 25716880. Abstract Subcellular distribution of FTY720 and FTY720-phosphate in immune cells - another aspect of Fingolimod action relevant for therapeutic application. Schröder M, Arlt O, Schmidt H, Huwiler A, Angioni C, Pfeilschifter JM, Schwiebs A, Radeke HH Biol Chem. 2015 Jan 14. PMID: 25720062. Abstract Estimating the marginal effect of socioeconomic factors on the demand of specialty drugs. Hosseini Jebeli S S, Barouni M, Orojloo P H, Mehraban S Glob J Health Sci. 2015; 7(2):40633. PMID: 25716405. Abstract Leflunomide and teriflunomide: altering the metabolism of pyrimidines for the treatment of autoimmune diseases. Fragoso Y D, Brooks J B B Expert Rev Clin Pharmacol. 2015 Feb 24:1-6. PMID: 25712857. Abstract Development of a cross-cultural item bank for measuring quality of life related to mental health in multiple sclerosis patients. Michel P, Auquier P, Baumstarck K, Pelletier J, Loundou A, Ghattas B, Boyer L Qual Life Res. 2015 Feb 25. PMID: 25712324. Abstract B cell VLA-4-deficiency reduces leukocyte recruitment and susceptibility to central nervous system autoimmunity. Lehmann-Horn K, Sagan SA, Bernard CCA, Sobel RA, Zamvil SS Ann Neurol. 2015 Feb 23. PMID: 25712734. Abstract A 60-year follow-up of the incidence and prevalence of multiple sclerosis in Hordaland County, Western Norway. Grytten N, Aarseth JH, Lunde HMB, Myhr KM J Neurol Neurosurg Psychiatry. 2015 Feb 24. PMID: 25714916. Abstract Severe anemia in a patient with multiple sclerosis treated with natalizumab. Seibert JB, Alvarez E Neurology. 2015 Feb 24; 84(8):861. PMID: 25713115. Abstract Exercise as a therapy for improvement of walking ability in adults with multiple sclerosis: A meta-analysis. Pearson M, Dieberg G, Smart N Arch Phys Med Rehabil. 2015 Feb 21. PMID: 25712347. Abstract Optical Coherence Tomography versus Visual Evoked Potentials in detecting subclinical visual impairment in multiple sclerosis. Grecescu M J Med Life. 2014 Oct-Dec; 7(4):538-41. PMID: 25713617. Abstract Iron-based superparamagnetic nanoparticle contrast agents for MRI of infection and inflammation. Neuwelt A, Sidhu N, Hu C-AA, Mlady G, Eberhardt SC, Sillerud LO AJR Am J Roentgenol. 2015 Mar; 204(3):W302-13. PMID: 25714316. Abstract Quality of life and patient preferences: identification of subgroups of multiple sclerosis patients. Rosato R, Testa S, Oggero A, Molinengo G, Bertolotto A Qual Life Res. 2015 Feb 26. Epub 2015 Feb 26. PMID: 25715945. Abstract The role of IL-17 in CNS diseases. Waisman A, Hauptmann J, Regen T Acta Neuropathol. 2015 Feb 26. Epub 2015 Feb 26. PMID: 25716179. Abstract A rare brain infection with multiple sclerosis dug. Aschenbrenner DS Am J Nurs. 2015 Mar; 115(3):22-3. PMID: 25715215. Abstract Frequency of Blood-tissue Parasitic Infections in Patients with Multiple Sclerosis, as Compared to their Family Members. Pestehchian N, Etemadifarr M, Yousefi H-A, Chiani M, Aslani N, Nasr Z Int J Prev Med. 2014 Dec; 5(12):1578-81. PMID: 25709793. Abstract [Assessment of the effectiveness and safety of Sativex ® in compassionate use]. Cimas-Hernando I, Pato-Pato A, Lorenzo-Gonzalez JR, Rodriguez-Constenla I Rev Neurol. 2015 Mar 1; 60(5):202-6. PMID: 25710689. Abstract Canonical Wnt Signaling in Dendritic Cells Regulates Th1/Th17 Responses and Suppresses Autoimmune Neuroinflammation. Suryawanshi A, Manoharan I, Hong Y, Swafford D, Majumdar T, Taketo MM, Manicassamy B, Koni PA, Thangaraju M, Sun Z, et al. J Immunol. 2015 Feb 20. PMID: 25710911. Abstract Relationship between Sleep Quality and Quality of Life in Patients with Multiple Sclerosis. Sarraf P, Azizi S, Moghaddasi A N, Sahraian M A, Tafakhori A, Ghajarzadeh M Int J Prev Med. 2014 Dec; 5(12):1582-6. PMID: 25709794. Abstract The role of information system in multiple sclerosis management. Ajami S, Ahmadi G, Etemadifar M J Res Med Sci. 2014 Dec; 19(12):1175-84. PMID: 25709660. Abstract Focal transient CNS vessel leak provides a tissue niche for sequential immune cell accumulation during the asymptomatic phase of EAE induction. Barkauskas DS, Dixon Dorand R, Myers JT, Evans TA, Barkauskas KJ, Askew D, Purgert R, Huang AY Exp Neurol. 2015 Feb 20; 266C:74-85. PMID: 25708987. Abstract Monoclonal antibody therapy in multiple sclerosis: critical appraisal and new perspectives. D'Amico E, Caserta C, Patti F Expert Rev Neurother. 2015 Mar; 15(3):251-68. PMID: 25708308. Abstract Accuracy and Reproducibility of a Quantitative Magnetic Resonance Imaging Method for Concurrent Measurements of Tissue Relaxation Times and Proton Density. Krauss W, Gunnarsson M, Andersson T, Thunberg P Magn Reson Imaging. 2015 Feb 20. PMID: 25708264. Abstract Dynamics and Mechanisms of CNS Myelination. Bercury KK, Macklin WB Dev Cell. 2015 Feb 23; 32(4):447-458. PMID: 25710531. Abstract Microglia: Multitasking Specialists of the Brain. Casano A M, Peri F Dev Cell. 2015 Feb 23; 32(4):469-477. PMID: 25710533. Abstract Dimethyl fumarat - a new player in oral treatment options for relapsing forms of multiple sclerosis. Antochi F Maedica (Buchar). 2014 Dec; 9(4):408-9. PMID: 25705316. Abstract Balance and Gait in People with Multiple Sclerosis: A Comparison with Healthy Controls and the Immediate Change after an Intervention based on the Bobath Concept. Ilett P, Lythgo N, Martin C, Brock K Physiother Res Int. 2015 Feb 20. PMID: 25704137. Abstract Metabolic Control of Th17 Cell Generation and CNS Inflammation. Yang K, Chi H J Neurol Neurophysiol. 2014; Suppl 12. PMID: 25705564. Abstract Neuropsychiatric side-effects of interferon-alpha treatment: pathophysiology and therapeutic options. Zahiu C D M, Rimbas M Maedica (Buchar). 2014 Jun; 9(2):121-6. PMID: 25705266. Abstract Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells. Jean-Gilles L, Braitch M, Latif M, Aram J, Fahey AJ, Edwards LJ, Adrian Robins R, Tanasescu R, Tighe PJ, Gran B, et al. Acta Physiol (Oxf). 2015 Feb 23. PMID: 25704169. Abstract Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination. Haines JD, Herbin O, de la Hera B, Vidaurre OG, Moy GA, Sun Q, Fung H Y J, Albrecht S, Alexandropoulos K, McCauley D, et al. Nat Neurosci. 2015 Apr; 18(4):511-520. Epub 2015 Feb 23. PMID: 25706475. Abstract [Do new oral therapies show advantages in the basal therapy of multiple sclerosis? Con.] Linker RA Nervenarzt. 2015 Feb 20. PMID: 25694252. Abstract Fall Incidence as the Primary Outcome in Multiple Sclerosis Falls-Prevention Trials: Recommendation from the International MS Falls Prevention Research Network. Coote S, Sosnoff JJ, Gunn H Int J MS Care. 2014 Winter; 16(4):178-84. PMID: 25694776. Abstract Control of Human PLP1 Expression Through Transcriptional Regulatory Elements and Alternatively Spliced Exons in Intron 1. Hamdan H, Kockara NT, Jolly L A, Haun S, Wight PA ASN Neuro. 2015 Feb; 7(1). PMID: 25694552. Abstract Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Induced Leukocyte Migration. Song J, Wu C, Korpos E, Zhang X, Agrawal SM, Wang Y, Faber C, Schäfers M, Körner H, Opdenakker G, et al. Cell Rep. 2015 Feb 24; 10(7):1040-54. Epub 2015 Feb 19. PMID: 25704809. Abstract Teriflunomide for the treatment of relapsing-remitting multiple sclerosis: patient preference and adherence. Bayas A, Mäurer M Patient Prefer Adherence. 2015; 9:265-74. Epub 2015 Feb 09. PMID: 25709412. Abstract Multiple Sclerosis Increases Fracture Risk: A Meta-Analysis. Dong G, Zhang N, Wu Z, Liu Y, Wang L Biomed Res Int. 2015; 2015:650138. Epub 2015 Feb 01. PMID: 25710014. Abstract Role of the Immunogenic and Tolerogenic Subsets of Dendritic Cells in Multiple Sclerosis. Xie Z-X, Zhang H-L, Wu X-J, Zhu J, Ma D-H, Jin T Mediators Inflamm. 2015; 2015:513295. Epub 2015 Jan 29. PMID: 25705093. Abstract
Editors' Pick The best basic science paper in multiple sclerosis in 2014: Important role for the choroid plexus in the central nervous system entry of leukocytes. Kooij G, de Vries HE Mult Scler. 2015 Feb 25. Epub 1969 Dec 31. PMID: 25716882. Abstract
Editors' Pick The outcome spectrum of multiple sclerosis: disability, mortality, and a cluster of predictors from onset. Tedeholm H, Skoog B, Lisovskaja V, Runmarker B, Nerman O, Andersen O J Neurol. 2015 Feb 26. Epub 1969 Dec 31. PMID: 25712541. Abstract
Neurodegenerative diseases and therapeutic strategies using iron chelators. Ward RJ, Dexter DT, Crichton RR J Trace Elem Med Biol. 2015 Jan 22. PMID: 25716300. Abstract
Neuromyelitis optica spectrum disorder as a paraneoplastic manifestation of lung adenocarcinoma expressing aquaporin-4. Iorio R, Rindi G, Erra C, Damato V, Ferilli M, Sabatelli M Mult Scler. 2015 Feb 25. PMID: 25716881. Abstract
Anti-muscarinic adjunct therapy accelerates functional human oligodendrocyte repair. Abiraman K, Pol SU, O'Bara MA, Chen G-D, Khaku ZM, Wang J, Thorn D, Vedia BH, Ekwegbalu EC, Li J-X, et al. J Neurosci. 2015 Feb 25; 35(8):3676-88. PMID: 25716865. Abstract
Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome. Disanto G, Adiutori R, Dobson R, Martinelli V, Dalla Costa G, Runia T, Evdoshenko E, Thouvenot E, Trojano M, Norgren N, et al. J Neurol Neurosurg Psychiatry. 2015 Feb 25. PMID: 25716934. Abstract
Cost Effectiveness Analysis of Avonex and CinnoVex in Relapsing Remitting MS. Najafi B, Ghaderi H, Jafari M, Najafi S, Ahmad Kiadaliri A Glob J Health Sci. 2015; 7(2):38659. PMID: 25716386. Abstract
Patient perspectives on physician conflict of interest in industry-sponsored clinical trials for multiple sclerosis therapeutics. Solomon AJ, Klein EP, Corboy JR, Bernat JL Mult Scler. 2015 Feb 25. PMID: 25716879. Abstract
A randomized, controlled, single-blind, 6-month pilot study to evaluate the efficacy of MS-Line!: a cognitive rehabilitation programme for patients with multiple sclerosis. Gich J, Freixanet J, García R, Vilanova J C, Genís D, Silva Y, Montalban X, Ramió-Torrentà L Mult Scler. 2015 Feb 25. PMID: 25716880. Abstract
Subcellular distribution of FTY720 and FTY720-phosphate in immune cells - another aspect of Fingolimod action relevant for therapeutic application. Schröder M, Arlt O, Schmidt H, Huwiler A, Angioni C, Pfeilschifter JM, Schwiebs A, Radeke HH Biol Chem. 2015 Jan 14. PMID: 25720062. Abstract
Estimating the marginal effect of socioeconomic factors on the demand of specialty drugs. Hosseini Jebeli S S, Barouni M, Orojloo P H, Mehraban S Glob J Health Sci. 2015; 7(2):40633. PMID: 25716405. Abstract
Leflunomide and teriflunomide: altering the metabolism of pyrimidines for the treatment of autoimmune diseases. Fragoso Y D, Brooks J B B Expert Rev Clin Pharmacol. 2015 Feb 24:1-6. PMID: 25712857. Abstract
Development of a cross-cultural item bank for measuring quality of life related to mental health in multiple sclerosis patients. Michel P, Auquier P, Baumstarck K, Pelletier J, Loundou A, Ghattas B, Boyer L Qual Life Res. 2015 Feb 25. PMID: 25712324. Abstract
B cell VLA-4-deficiency reduces leukocyte recruitment and susceptibility to central nervous system autoimmunity. Lehmann-Horn K, Sagan SA, Bernard CCA, Sobel RA, Zamvil SS Ann Neurol. 2015 Feb 23. PMID: 25712734. Abstract
A 60-year follow-up of the incidence and prevalence of multiple sclerosis in Hordaland County, Western Norway. Grytten N, Aarseth JH, Lunde HMB, Myhr KM J Neurol Neurosurg Psychiatry. 2015 Feb 24. PMID: 25714916. Abstract
Severe anemia in a patient with multiple sclerosis treated with natalizumab. Seibert JB, Alvarez E Neurology. 2015 Feb 24; 84(8):861. PMID: 25713115. Abstract
Exercise as a therapy for improvement of walking ability in adults with multiple sclerosis: A meta-analysis. Pearson M, Dieberg G, Smart N Arch Phys Med Rehabil. 2015 Feb 21. PMID: 25712347. Abstract
Optical Coherence Tomography versus Visual Evoked Potentials in detecting subclinical visual impairment in multiple sclerosis. Grecescu M J Med Life. 2014 Oct-Dec; 7(4):538-41. PMID: 25713617. Abstract
Iron-based superparamagnetic nanoparticle contrast agents for MRI of infection and inflammation. Neuwelt A, Sidhu N, Hu C-AA, Mlady G, Eberhardt SC, Sillerud LO AJR Am J Roentgenol. 2015 Mar; 204(3):W302-13. PMID: 25714316. Abstract
Quality of life and patient preferences: identification of subgroups of multiple sclerosis patients. Rosato R, Testa S, Oggero A, Molinengo G, Bertolotto A Qual Life Res. 2015 Feb 26. Epub 2015 Feb 26. PMID: 25715945. Abstract
The role of IL-17 in CNS diseases. Waisman A, Hauptmann J, Regen T Acta Neuropathol. 2015 Feb 26. Epub 2015 Feb 26. PMID: 25716179. Abstract
A rare brain infection with multiple sclerosis dug. Aschenbrenner DS Am J Nurs. 2015 Mar; 115(3):22-3. PMID: 25715215. Abstract
Frequency of Blood-tissue Parasitic Infections in Patients with Multiple Sclerosis, as Compared to their Family Members. Pestehchian N, Etemadifarr M, Yousefi H-A, Chiani M, Aslani N, Nasr Z Int J Prev Med. 2014 Dec; 5(12):1578-81. PMID: 25709793. Abstract
[Assessment of the effectiveness and safety of Sativex ® in compassionate use]. Cimas-Hernando I, Pato-Pato A, Lorenzo-Gonzalez JR, Rodriguez-Constenla I Rev Neurol. 2015 Mar 1; 60(5):202-6. PMID: 25710689. Abstract
Canonical Wnt Signaling in Dendritic Cells Regulates Th1/Th17 Responses and Suppresses Autoimmune Neuroinflammation. Suryawanshi A, Manoharan I, Hong Y, Swafford D, Majumdar T, Taketo MM, Manicassamy B, Koni PA, Thangaraju M, Sun Z, et al. J Immunol. 2015 Feb 20. PMID: 25710911. Abstract
Relationship between Sleep Quality and Quality of Life in Patients with Multiple Sclerosis. Sarraf P, Azizi S, Moghaddasi A N, Sahraian M A, Tafakhori A, Ghajarzadeh M Int J Prev Med. 2014 Dec; 5(12):1582-6. PMID: 25709794. Abstract
The role of information system in multiple sclerosis management. Ajami S, Ahmadi G, Etemadifar M J Res Med Sci. 2014 Dec; 19(12):1175-84. PMID: 25709660. Abstract
Focal transient CNS vessel leak provides a tissue niche for sequential immune cell accumulation during the asymptomatic phase of EAE induction. Barkauskas DS, Dixon Dorand R, Myers JT, Evans TA, Barkauskas KJ, Askew D, Purgert R, Huang AY Exp Neurol. 2015 Feb 20; 266C:74-85. PMID: 25708987. Abstract
Monoclonal antibody therapy in multiple sclerosis: critical appraisal and new perspectives. D'Amico E, Caserta C, Patti F Expert Rev Neurother. 2015 Mar; 15(3):251-68. PMID: 25708308. Abstract
Accuracy and Reproducibility of a Quantitative Magnetic Resonance Imaging Method for Concurrent Measurements of Tissue Relaxation Times and Proton Density. Krauss W, Gunnarsson M, Andersson T, Thunberg P Magn Reson Imaging. 2015 Feb 20. PMID: 25708264. Abstract
Dynamics and Mechanisms of CNS Myelination. Bercury KK, Macklin WB Dev Cell. 2015 Feb 23; 32(4):447-458. PMID: 25710531. Abstract
Microglia: Multitasking Specialists of the Brain. Casano A M, Peri F Dev Cell. 2015 Feb 23; 32(4):469-477. PMID: 25710533. Abstract
Dimethyl fumarat - a new player in oral treatment options for relapsing forms of multiple sclerosis. Antochi F Maedica (Buchar). 2014 Dec; 9(4):408-9. PMID: 25705316. Abstract
Balance and Gait in People with Multiple Sclerosis: A Comparison with Healthy Controls and the Immediate Change after an Intervention based on the Bobath Concept. Ilett P, Lythgo N, Martin C, Brock K Physiother Res Int. 2015 Feb 20. PMID: 25704137. Abstract
Metabolic Control of Th17 Cell Generation and CNS Inflammation. Yang K, Chi H J Neurol Neurophysiol. 2014; Suppl 12. PMID: 25705564. Abstract
Neuropsychiatric side-effects of interferon-alpha treatment: pathophysiology and therapeutic options. Zahiu C D M, Rimbas M Maedica (Buchar). 2014 Jun; 9(2):121-6. PMID: 25705266. Abstract
Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells. Jean-Gilles L, Braitch M, Latif M, Aram J, Fahey AJ, Edwards LJ, Adrian Robins R, Tanasescu R, Tighe PJ, Gran B, et al. Acta Physiol (Oxf). 2015 Feb 23. PMID: 25704169. Abstract
Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination. Haines JD, Herbin O, de la Hera B, Vidaurre OG, Moy GA, Sun Q, Fung H Y J, Albrecht S, Alexandropoulos K, McCauley D, et al. Nat Neurosci. 2015 Apr; 18(4):511-520. Epub 2015 Feb 23. PMID: 25706475. Abstract
[Do new oral therapies show advantages in the basal therapy of multiple sclerosis? Con.] Linker RA Nervenarzt. 2015 Feb 20. PMID: 25694252. Abstract
Fall Incidence as the Primary Outcome in Multiple Sclerosis Falls-Prevention Trials: Recommendation from the International MS Falls Prevention Research Network. Coote S, Sosnoff JJ, Gunn H Int J MS Care. 2014 Winter; 16(4):178-84. PMID: 25694776. Abstract
Control of Human PLP1 Expression Through Transcriptional Regulatory Elements and Alternatively Spliced Exons in Intron 1. Hamdan H, Kockara NT, Jolly L A, Haun S, Wight PA ASN Neuro. 2015 Feb; 7(1). PMID: 25694552. Abstract
Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Induced Leukocyte Migration. Song J, Wu C, Korpos E, Zhang X, Agrawal SM, Wang Y, Faber C, Schäfers M, Körner H, Opdenakker G, et al. Cell Rep. 2015 Feb 24; 10(7):1040-54. Epub 2015 Feb 19. PMID: 25704809. Abstract
Teriflunomide for the treatment of relapsing-remitting multiple sclerosis: patient preference and adherence. Bayas A, Mäurer M Patient Prefer Adherence. 2015; 9:265-74. Epub 2015 Feb 09. PMID: 25709412. Abstract
Multiple Sclerosis Increases Fracture Risk: A Meta-Analysis. Dong G, Zhang N, Wu Z, Liu Y, Wang L Biomed Res Int. 2015; 2015:650138. Epub 2015 Feb 01. PMID: 25710014. Abstract
Role of the Immunogenic and Tolerogenic Subsets of Dendritic Cells in Multiple Sclerosis. Xie Z-X, Zhang H-L, Wu X-J, Zhu J, Ma D-H, Jin T Mediators Inflamm. 2015; 2015:513295. Epub 2015 Jan 29. PMID: 25705093. Abstract