Papers: 12 Dec 2014 - 19 Dec 2014 Check out this week's papers from PubMed. If you are a member, please log in to recommend and comment on papers. If you are not a member, please register today and join the conversation. Papers: Editors' Pick Please mind the gap: axonal transport deficits in multiple sclerosis neurodegeneration. Dendrou CA, Fugger L Neuron. 2014 Dec 17; 84(6):1105-7. Epub 1969 Dec 31. PMID: 25521369. Abstract Editors' Pick Ten-year prognosis in multiple sclerosis: a better outcome in relapsing-remitting patients but not in primary progressive patients. Kerbrat A, Hamonic S, Leray E, Tron I, Edan G, Yaouanq J, within the West Neuroscience Network of Excellence(WENNE) Eur J Neurol. 2014 Dec 16. Epub 1969 Dec 31. PMID: 25515927. Abstract Biological relevance of citrullinations: diagnostic, prognostic and therapeutic options. Gudmann NS, Hansen NUB, Jensen ACB, Karsdal MA, Siebuhr AS Autoimmunity. 2014 Dec 18:1-7. PMID: 25520183. Abstract Predictive Value of Baseline Electronic Columbia-Suicide Severity Rating Scale (eC-SSRS) Assessments for Identifying Risk of Prospective Reports of Suicidal Behavior During Research Participation. Greist JH, Mundt JC, Gwaltney CJ, Jefferson JW, Posner K Innov Clin Neurosci. 2014 Sep; 11(9-10):23-31. PMID: 25520886. Abstract High-affinity sigma-1 protein agonist reduces clinical and pathological signs of experimental auto-immune encephalomyelitis. Oxombre B, Lee-Chang C, Duhamel A, Toussaint M, Giroux M, Donnier-Maréchal M, Carato P, Lefranc D, Zéphir H, Prin L, et al. Br J Pharmacol. 2014 Dec 17. PMID: 25521311. Abstract Cognitive impairment in multiple sclerosis: clinical, radiologic and pathologic insights. Deluca GC, Yates RL, Beale H, Morrow SA Brain Pathol. 2015 Jan; 25(1):79-98. PMID: 25521179. Abstract Neuropathological Techniques to Investigate Central Nervous System Sections in Multiple Sclerosis. Bauer J, Lassmann H Methods Mol Biol. 2014 Dec 18. PMID: 25520281. Abstract Psychiatric comorbidity in multiple sclerosis: It's not the genes. Marrie R A Mult Scler. 2014 Dec; 20(14):1803-5. PMID: 25520402. Abstract Identification of biomarkers in cerebrospinal fluid and serum of multiple sclerosis patients by immunoproteomics approach. Colomba P, Fontana S, Salemi G, Barranca M, Sicco C L, Mazzola M A, Ragonese P, Savettieri G, De Leo G, Alessandro R, et al. Int J Mol Sci. 2014; 15(12):23269-82. PMID: 25517032. Abstract Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells. Ikeda T, Hirata S, Takamatsu K, Haruta M, Tsukamoto H, Ito T, Uchino M, Ando Y, Nagafuchi S, Nishimura Y, et al. PLoS One. 2014; 9(12):e115198. Epub 2014 Dec 18. PMID: 25522369. Abstract Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation. Wu D, Cerutti C, Lopez-Ramirez MA, Pryce G, King-Robson J, Simpson JE, van der Pol SMA, Hirst MC, de Vries HE, Sharrack B, et al. J Cereb Blood Flow Metab. 2014 Dec 17. PMID: 25515214. Abstract Natalizumab treatment for multiple sclerosis. Ferreira M L B Arq Neuropsiquiatr. 2014 Dec; 72(12):911-2. PMID: 25517640. Abstract Health-related quality of life in partners of persons with MS: a longitudinal 10-year perspective. Gottberg K, Chruzander C, Einarsson U, Fredrikson S, Johansson S, Widén Holmqvist L BMJ Open. 2014; 4(12):e006097. PMID: 25515842. Abstract Oxidative stress induced by lipid peroxidation is related with inflammation of demyelination and neurodegeneration in multiple sclerosis. Wang P, Xie K, Wang C, Bi J Eur Neurol. 2014; 72(3-4):249-54. PMID: 25512984. Abstract Quantifying progression of multiple sclerosis via classification of depth videos. Kontschieder P, Dorn JF, Morrison C, Corish R, Zikic D, Sellen A, D'Souza M, Kamm CP, Burggraaff J, Tewarie P, et al. Med Image Comput Comput Assist Interv. 2014; 17(Pt 2):429-37. PMID: 25513540. Abstract A modality-agnostic patch-based technique for lesion filling in multiple sclerosis. Prados F, Cardoso M J, Macmanus D, Wheeler-Kingshott C A, Ourselin S Med Image Comput Comput Assist Interv. 2014; 17(Pt 2):781-8. PMID: 25513583. Abstract Spatial modeling of multiple sclerosis for disease subtype prediction. Taschler B, Ge T, Bendfeldt K, Müller-Lenke N, Johnson TD, Nichols TE Med Image Comput Comput Assist Interv. 2014; 17(Pt 2):797-804. PMID: 25513585. Abstract Leukemia inhibitory factor tips the immune balance towards regulatory T cells in multiple sclerosis. Janssens K, Van Den Haute C, Baekelandt V, Lucas S, van Horssen J, Van Wijmeersch B, Stinissen P, Hendriks JJA, Slaets H, Hellings N, et al. Brain Behav Immun. 2014 Dec 13. PMID: 25514345. Abstract Modeling the variability in brain morphology and lesion distribution in multiple sclerosis by deep learning. Brosch T, Yoo Y, Li DKB, Traboulsee A, Tam R Med Image Comput Comput Assist Interv. 2014; 17(Pt 2):462-9. PMID: 25513544. Abstract Multiple sclerosis guideline production takes off. Maurice J Lancet. 2014 Nov 29; 384(9958):1914-5. PMID: 25513411. Abstract Leukotrienes induce the migration of Th17 cells. Lee W, Su Kim H, Lee G R Immunol Cell Biol. 2014 Dec 16. PMID: 25512344. Abstract Oral disease-modifying therapies for relapsing-remitting multiple sclerosis. Thomas R H, Wakefield RA Am J Health Syst Pharm. 2015 Jan 1; 72(1):25-38. PMID: 25511835. Abstract Natalizumab improves ambulation in relapsing-remitting multiple sclerosis: results from the prospective TIMER study and a retrospective analysis of AFFIRM. Voloshyna N, Havrdová E, Hutchinson M, Nehrych T, You X, Belachew S, Hotermans C, Paes D Eur J Neurol. 2014 Dec 15. PMID: 25511792. Abstract Diverse functional roles of lipocalin-2 in the central nervous system. Jha M K, Lee S, Park D H, Kook H, Park K-G, Lee I-K, Suk K Neurosci Biobehav Rev. 2014 Dec 12. PMID: 25511817. Abstract Dopaminergic dysfunction is associated with IL-1β-dependent mood alterations in experimental autoimmune encephalomyelitis. Gentile A, Fresegna D, Federici M, Musella A, Rizzo F R, Sepman H, Bullitta S, De Vito F, Haji N, Rossi S, et al. Neurobiol Dis. 2014 Dec 12; 74C:347-358. PMID: 25511803. Abstract Transcriptional expression of MBP in oligodendrocytes depends on functional syntaxin 4; a potential correlation with autocrine signalling. Bijlard M, Klunder B, de Jonge JC, Nomden A, Tyagi S, de Vries H, Hoekstra D, Baron W Mol Cell Biol. 2014 Dec 15. PMID: 25512606. Abstract Interferon-ß-related tumefactive brain lesion in a Caucasian patient with neuromyelitis optica and clinical stabilization with tocilizumab. Harmel J, Ringelstein M, Ingwersen J, Mathys C, Goebels N, Hartung H-P, Jarius S, Aktas O BMC Neurol. 2014 Dec 17; 14(1):247. Epub 2014 Dec 17. PMID: 25516429. Abstract Demyelinating disease: Is TOPIC the last trial for clinically isolated syndrome? Cree BAC Nat Rev Neurol. 2014 Dec 16. PMID: 25511890. Abstract The multiple sclerosis visual pathway cohort: understanding neurodegeneration in MS. Martínez-Lapiscina EH, Fraga-Pumar E, Gabilondo I, Martínez-Heras E, Torres-Torres R, Ortiz-Pérez S, Llufriu S, Tercero A, Andorra M, Roca M F, et al. BMC Res Notes. 2014; 7:910. Epub 2014 Dec 15. PMID: 25512202. Abstract Rituximab as a first-line preventive treatment in pediatric NMOSDs: Preliminary results in 5 children. Longoni G, Banwell B, Filippi M, Yeh AE Neurol Neuroimmunol Neuroinflamm. 2014 Dec; 1(4):e46. Epub 2014 Dec 11. PMID: 25520954. Abstract CB1 receptor affects cortical plasticity and response to physiotherapy in multiple sclerosis. Mori F, Ljoka C, Nicoletti CG, Kusayanagi H, Buttari F, Giordani L, Rossi S, Foti C, Centonze D Neurol Neuroimmunol Neuroinflamm. 2014 Dec; 1(4):e48. Epub 2014 Dec 11. PMID: 25520956. Abstract Natalizumab-related anaphylactoid reactions in MS patients are associated with HLA class II alleles. de la Hera B, Urcelay E, Brassat D, Chan A, Vidal-Jordana A, Salmen A, Villar L M, Alvarez-Cermeño J C, Izquierdo G, Fernández O, et al. Neurol Neuroimmunol Neuroinflamm. 2014 Dec; 1(4):e47. Epub 2014 Dec 11. PMID: 25520955. Abstract Perturbed glucose metabolism: insights into multiple sclerosis pathogenesis. Mathur D, López-Rodas G, Casanova B, Marti M B Front Neurol. 2014; 5:250. Epub 2014 Dec 01. PMID: 25520698. Abstract Damage to the optic chiasm in myelin oligodendrocyte glycoprotein-experimental autoimmune encephalomyelitis mice. Herrera SL, Palmer VL, Whittaker H, Smith B C, Kim A, Schellenberg AE, Thiessen JD, Buist R, Del Bigio MR, Martin M Magn Reson Insights. 2014; 7:23-31. Epub 2014 Nov 09. PMID: 25520558. Abstract Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor. Buzard DJ, Kim S H, Lopez L, Kawasaki A, Zhu X, Moody J, Thoresen L, Calderon I, Ullman B, Han S, et al. ACS Med Chem Lett. 2014 Dec 11; 5(12):1313-7. Epub 2014 Nov 04. PMID: 25516790. Abstract Anti-CD20 inhibits T cell-mediated pathology and microgliosis in the rat brain. Anthony DC, Dickens AM, Seneca N, Couch Y, Campbell S, Checa B, Kersemans V, Warren EA, Tredwell M, Sibson NR, et al. Ann Clin Transl Neurol. 2014 Sep; 1(9):659-69. Epub 2014 Sep 16. PMID: 25493280. Abstract Using Twitter to investigate opinions about multiple sclerosis treatments: a descriptive, exploratory study. Ramagopalan S, Wasiak R, Cox AP F1000Res. 2014; 3:216. Epub 2014 Sep 10. PMID: 25520780. Abstract Increased CXCL10 expression in MS MSCs and monocytes is unaffected by AHSCT. Bonechi E, Aldinucci A, Mazzanti B, di Gioia M, Repice A M, Manuelli C, Saccardi R, Massacesi L, Ballerini C Ann Clin Transl Neurol. 2014 Sep; 1(9):650-8. Epub 2014 Aug 29. PMID: 25493279. Abstract Unmet education, psychological and peer support needs of people with multiple sclerosis. McCabe MP, Ebacioni KJ, Simmons R, McDonald E, Melton L J Psychosom Res. 2015 Jan; 78(1):82-7. Epub 2014 Jun 05. PMID: 25516288. Abstract
Editors' Pick Please mind the gap: axonal transport deficits in multiple sclerosis neurodegeneration. Dendrou CA, Fugger L Neuron. 2014 Dec 17; 84(6):1105-7. Epub 1969 Dec 31. PMID: 25521369. Abstract
Editors' Pick Ten-year prognosis in multiple sclerosis: a better outcome in relapsing-remitting patients but not in primary progressive patients. Kerbrat A, Hamonic S, Leray E, Tron I, Edan G, Yaouanq J, within the West Neuroscience Network of Excellence(WENNE) Eur J Neurol. 2014 Dec 16. Epub 1969 Dec 31. PMID: 25515927. Abstract
Biological relevance of citrullinations: diagnostic, prognostic and therapeutic options. Gudmann NS, Hansen NUB, Jensen ACB, Karsdal MA, Siebuhr AS Autoimmunity. 2014 Dec 18:1-7. PMID: 25520183. Abstract
Predictive Value of Baseline Electronic Columbia-Suicide Severity Rating Scale (eC-SSRS) Assessments for Identifying Risk of Prospective Reports of Suicidal Behavior During Research Participation. Greist JH, Mundt JC, Gwaltney CJ, Jefferson JW, Posner K Innov Clin Neurosci. 2014 Sep; 11(9-10):23-31. PMID: 25520886. Abstract
High-affinity sigma-1 protein agonist reduces clinical and pathological signs of experimental auto-immune encephalomyelitis. Oxombre B, Lee-Chang C, Duhamel A, Toussaint M, Giroux M, Donnier-Maréchal M, Carato P, Lefranc D, Zéphir H, Prin L, et al. Br J Pharmacol. 2014 Dec 17. PMID: 25521311. Abstract
Cognitive impairment in multiple sclerosis: clinical, radiologic and pathologic insights. Deluca GC, Yates RL, Beale H, Morrow SA Brain Pathol. 2015 Jan; 25(1):79-98. PMID: 25521179. Abstract
Neuropathological Techniques to Investigate Central Nervous System Sections in Multiple Sclerosis. Bauer J, Lassmann H Methods Mol Biol. 2014 Dec 18. PMID: 25520281. Abstract
Psychiatric comorbidity in multiple sclerosis: It's not the genes. Marrie R A Mult Scler. 2014 Dec; 20(14):1803-5. PMID: 25520402. Abstract
Identification of biomarkers in cerebrospinal fluid and serum of multiple sclerosis patients by immunoproteomics approach. Colomba P, Fontana S, Salemi G, Barranca M, Sicco C L, Mazzola M A, Ragonese P, Savettieri G, De Leo G, Alessandro R, et al. Int J Mol Sci. 2014; 15(12):23269-82. PMID: 25517032. Abstract
Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells. Ikeda T, Hirata S, Takamatsu K, Haruta M, Tsukamoto H, Ito T, Uchino M, Ando Y, Nagafuchi S, Nishimura Y, et al. PLoS One. 2014; 9(12):e115198. Epub 2014 Dec 18. PMID: 25522369. Abstract
Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation. Wu D, Cerutti C, Lopez-Ramirez MA, Pryce G, King-Robson J, Simpson JE, van der Pol SMA, Hirst MC, de Vries HE, Sharrack B, et al. J Cereb Blood Flow Metab. 2014 Dec 17. PMID: 25515214. Abstract
Natalizumab treatment for multiple sclerosis. Ferreira M L B Arq Neuropsiquiatr. 2014 Dec; 72(12):911-2. PMID: 25517640. Abstract
Health-related quality of life in partners of persons with MS: a longitudinal 10-year perspective. Gottberg K, Chruzander C, Einarsson U, Fredrikson S, Johansson S, Widén Holmqvist L BMJ Open. 2014; 4(12):e006097. PMID: 25515842. Abstract
Oxidative stress induced by lipid peroxidation is related with inflammation of demyelination and neurodegeneration in multiple sclerosis. Wang P, Xie K, Wang C, Bi J Eur Neurol. 2014; 72(3-4):249-54. PMID: 25512984. Abstract
Quantifying progression of multiple sclerosis via classification of depth videos. Kontschieder P, Dorn JF, Morrison C, Corish R, Zikic D, Sellen A, D'Souza M, Kamm CP, Burggraaff J, Tewarie P, et al. Med Image Comput Comput Assist Interv. 2014; 17(Pt 2):429-37. PMID: 25513540. Abstract
A modality-agnostic patch-based technique for lesion filling in multiple sclerosis. Prados F, Cardoso M J, Macmanus D, Wheeler-Kingshott C A, Ourselin S Med Image Comput Comput Assist Interv. 2014; 17(Pt 2):781-8. PMID: 25513583. Abstract
Spatial modeling of multiple sclerosis for disease subtype prediction. Taschler B, Ge T, Bendfeldt K, Müller-Lenke N, Johnson TD, Nichols TE Med Image Comput Comput Assist Interv. 2014; 17(Pt 2):797-804. PMID: 25513585. Abstract
Leukemia inhibitory factor tips the immune balance towards regulatory T cells in multiple sclerosis. Janssens K, Van Den Haute C, Baekelandt V, Lucas S, van Horssen J, Van Wijmeersch B, Stinissen P, Hendriks JJA, Slaets H, Hellings N, et al. Brain Behav Immun. 2014 Dec 13. PMID: 25514345. Abstract
Modeling the variability in brain morphology and lesion distribution in multiple sclerosis by deep learning. Brosch T, Yoo Y, Li DKB, Traboulsee A, Tam R Med Image Comput Comput Assist Interv. 2014; 17(Pt 2):462-9. PMID: 25513544. Abstract
Multiple sclerosis guideline production takes off. Maurice J Lancet. 2014 Nov 29; 384(9958):1914-5. PMID: 25513411. Abstract
Leukotrienes induce the migration of Th17 cells. Lee W, Su Kim H, Lee G R Immunol Cell Biol. 2014 Dec 16. PMID: 25512344. Abstract
Oral disease-modifying therapies for relapsing-remitting multiple sclerosis. Thomas R H, Wakefield RA Am J Health Syst Pharm. 2015 Jan 1; 72(1):25-38. PMID: 25511835. Abstract
Natalizumab improves ambulation in relapsing-remitting multiple sclerosis: results from the prospective TIMER study and a retrospective analysis of AFFIRM. Voloshyna N, Havrdová E, Hutchinson M, Nehrych T, You X, Belachew S, Hotermans C, Paes D Eur J Neurol. 2014 Dec 15. PMID: 25511792. Abstract
Diverse functional roles of lipocalin-2 in the central nervous system. Jha M K, Lee S, Park D H, Kook H, Park K-G, Lee I-K, Suk K Neurosci Biobehav Rev. 2014 Dec 12. PMID: 25511817. Abstract
Dopaminergic dysfunction is associated with IL-1β-dependent mood alterations in experimental autoimmune encephalomyelitis. Gentile A, Fresegna D, Federici M, Musella A, Rizzo F R, Sepman H, Bullitta S, De Vito F, Haji N, Rossi S, et al. Neurobiol Dis. 2014 Dec 12; 74C:347-358. PMID: 25511803. Abstract
Transcriptional expression of MBP in oligodendrocytes depends on functional syntaxin 4; a potential correlation with autocrine signalling. Bijlard M, Klunder B, de Jonge JC, Nomden A, Tyagi S, de Vries H, Hoekstra D, Baron W Mol Cell Biol. 2014 Dec 15. PMID: 25512606. Abstract
Interferon-ß-related tumefactive brain lesion in a Caucasian patient with neuromyelitis optica and clinical stabilization with tocilizumab. Harmel J, Ringelstein M, Ingwersen J, Mathys C, Goebels N, Hartung H-P, Jarius S, Aktas O BMC Neurol. 2014 Dec 17; 14(1):247. Epub 2014 Dec 17. PMID: 25516429. Abstract
Demyelinating disease: Is TOPIC the last trial for clinically isolated syndrome? Cree BAC Nat Rev Neurol. 2014 Dec 16. PMID: 25511890. Abstract
The multiple sclerosis visual pathway cohort: understanding neurodegeneration in MS. Martínez-Lapiscina EH, Fraga-Pumar E, Gabilondo I, Martínez-Heras E, Torres-Torres R, Ortiz-Pérez S, Llufriu S, Tercero A, Andorra M, Roca M F, et al. BMC Res Notes. 2014; 7:910. Epub 2014 Dec 15. PMID: 25512202. Abstract
Rituximab as a first-line preventive treatment in pediatric NMOSDs: Preliminary results in 5 children. Longoni G, Banwell B, Filippi M, Yeh AE Neurol Neuroimmunol Neuroinflamm. 2014 Dec; 1(4):e46. Epub 2014 Dec 11. PMID: 25520954. Abstract
CB1 receptor affects cortical plasticity and response to physiotherapy in multiple sclerosis. Mori F, Ljoka C, Nicoletti CG, Kusayanagi H, Buttari F, Giordani L, Rossi S, Foti C, Centonze D Neurol Neuroimmunol Neuroinflamm. 2014 Dec; 1(4):e48. Epub 2014 Dec 11. PMID: 25520956. Abstract
Natalizumab-related anaphylactoid reactions in MS patients are associated with HLA class II alleles. de la Hera B, Urcelay E, Brassat D, Chan A, Vidal-Jordana A, Salmen A, Villar L M, Alvarez-Cermeño J C, Izquierdo G, Fernández O, et al. Neurol Neuroimmunol Neuroinflamm. 2014 Dec; 1(4):e47. Epub 2014 Dec 11. PMID: 25520955. Abstract
Perturbed glucose metabolism: insights into multiple sclerosis pathogenesis. Mathur D, López-Rodas G, Casanova B, Marti M B Front Neurol. 2014; 5:250. Epub 2014 Dec 01. PMID: 25520698. Abstract
Damage to the optic chiasm in myelin oligodendrocyte glycoprotein-experimental autoimmune encephalomyelitis mice. Herrera SL, Palmer VL, Whittaker H, Smith B C, Kim A, Schellenberg AE, Thiessen JD, Buist R, Del Bigio MR, Martin M Magn Reson Insights. 2014; 7:23-31. Epub 2014 Nov 09. PMID: 25520558. Abstract
Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor. Buzard DJ, Kim S H, Lopez L, Kawasaki A, Zhu X, Moody J, Thoresen L, Calderon I, Ullman B, Han S, et al. ACS Med Chem Lett. 2014 Dec 11; 5(12):1313-7. Epub 2014 Nov 04. PMID: 25516790. Abstract
Anti-CD20 inhibits T cell-mediated pathology and microgliosis in the rat brain. Anthony DC, Dickens AM, Seneca N, Couch Y, Campbell S, Checa B, Kersemans V, Warren EA, Tredwell M, Sibson NR, et al. Ann Clin Transl Neurol. 2014 Sep; 1(9):659-69. Epub 2014 Sep 16. PMID: 25493280. Abstract
Using Twitter to investigate opinions about multiple sclerosis treatments: a descriptive, exploratory study. Ramagopalan S, Wasiak R, Cox AP F1000Res. 2014; 3:216. Epub 2014 Sep 10. PMID: 25520780. Abstract
Increased CXCL10 expression in MS MSCs and monocytes is unaffected by AHSCT. Bonechi E, Aldinucci A, Mazzanti B, di Gioia M, Repice A M, Manuelli C, Saccardi R, Massacesi L, Ballerini C Ann Clin Transl Neurol. 2014 Sep; 1(9):650-8. Epub 2014 Aug 29. PMID: 25493279. Abstract
Unmet education, psychological and peer support needs of people with multiple sclerosis. McCabe MP, Ebacioni KJ, Simmons R, McDonald E, Melton L J Psychosom Res. 2015 Jan; 78(1):82-7. Epub 2014 Jun 05. PMID: 25516288. Abstract