Design, Biological Characterization, and Discovery of the Brain-Penetrant NLRP3 Inhibitor Based on a [1,2,4]Triazolo[1,5-]pyrimidine Scaffold for the Treatment of Central Nervous System Diseases.
He W, Zhang K, Jia X, Lv Y, Cheng T, Han L, Xia Y, Zhang X, Zhai W, Yang F, et al.
J Med Chem. 2026 Jul 09; 69(13):15766-15785. PMID: 42332435.Abstract
