Discovery of 4-((2S,5R)-2-((difluoromethoxy)methyl)-5-(4-(trifluoromethyl)phenyl)piperidin-1-yl)-N-((R)-1-(4-(ethylsulfonyl)phenyl)-2-hydroxyethyl)benzamide as a potent, orally available RORγt inverse agonist.
Cao W, Liu B, Kang N, Bai S, Wang F, Xue L, Li M, Cheng CC, Yang F, Zhang Y, et al.
Bioorg Chem. 2026 May 12; 179:109959. PMID: 42143843.Abstract
