Cytochrome P450 3A4 is the major enzyme responsible for the metabolism of laquinimod, a novel immunomodulator. Tuvesson H, Hallin I, Persson R, Sparre B, Gunnarsson P O, Seidegård J Drug Metab Dispos. 2005 Jun; 33(6):866-72. Epub 2005 Mar 11. PMID: 15764719. Abstract CommentRecommendBookmarkWatch