An Electrophoretic Study of the Protein Components in Cerebrospinal Fluid and their Relationship to the Serum Proteins.
Elvin Kabat pioneered the study of proteins in the spinal fluid and serum using electrophoresis. He showed there was an increase in the proportion of gamma globulins in the spinal fluid from patients with multiple sclerosis. This was a key finding in establishing MS as an immunological disorder and has been a major focus of research ever since. Some think the intrathecal antibody response will be the key to discovering the cause of MS.