IFNbeta lowers MMP-9/TIMP-1 ratio, which predicts new enhancing lesions in patients with SPMS. Waubant E, Goodkin D, Bostrom A, Bacchetti P, Hietpas J, Lindberg R, Leppert D Neurology. 2003 Jan 14; 60(1):52-7. PMID: 12525717. Abstract CommentRecommendBookmarkWatch