Effirma, Synthetic Biologics Synthetic Biologics Accessed on 14 May 2012 from http://www.syntheticbiologics.com/effirma.
Flupirtine Drugs.com Accessed on 14 Feb 2012 from http://www.drugs.com/international/flupirtine.html.
ChemIDplus Advanced United States National Library of Medicine Accessed on 29 Jul 2013 from http://chem.sis.nlm.nih.gov/chemidplus/chemidheavy.jsp. Note: Compound name must be entered under "Substance Identification" and then "Names and Synonyms" selected to view synonyms.
Flupirtine: pharmacology and clinical applications of a nonopioid analgesic and potentially neuroprotective compound. Klawe C, Maschke M Expert Opin Pharmacother. 2009 Jun; 10(9):1495-500. PMID: 19505216. Abstract
Product Portfolio, Meda Meda Accessed on 14 Feb 2012 from http://www.meda.se/product-portfolio/medas-pipeline/pain-and-inflammation/.
Flupirtine as neuroprotective add-on therapy in autoimmune optic neuritis. Sättler MB, Williams SK, Neusch C, Otto M, Pehlke JR, Bähr M, Diem R Am J Pathol. 2008 Nov; 173(5):1496-507. Epub 2008 Oct 02. PMID: 18832577. Abstract
Flupirtine in pain management: pharmacological properties and clinical use. Devulder J CNS Drugs. 2010 Oct; 24(10):867-81. PMID: 20839897. Abstract
Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study. Otto M, Cepek L, Ratzka P, Doehlinger S, Boekhoff I, Wiltfang J, Irle E, Pergande G, Ellers-Lenz B, Windl O, et al. Neurology. 2004 Mar 9; 62(5):714-8. PMID: 15007119. Abstract
[The effect of flupirtine, various analgesics and muscle relaxants on skeletal muscle tone in the conscious rat]. Nickel B, Jakovlev V, Szelenyi I Arzneimittelforschung. 1990 Aug; 40(8):909-11. PMID: 2242082. Abstract
Enhancement of axonal potassium conductance reduces nerve hyperexcitability in an in vitro model of oxaliplatin-induced acute neuropathy. Sittl R, Carr RW, Fleckenstein J, Grafe P Neurotoxicology. 2010 Dec; 31(6):694-700. Epub 2010 Jul 27. PMID: 20670646. Abstract
Antioxidant properties of the triaminopyridine, flupirtine. Gassen M, Pergande G, Youdim MB Biochem Pharmacol. 1998 Nov 15; 56(10):1323-9. PMID: 9825731. Abstract
Flupirtine as Oral Treatment in Multiple Sclerosis (FLORIMS) ClinicalTrials.gov, 10 Feb 2014 Accessed on 25 Aug 2014 from http://clinicaltrials.gov/ct2/show/NCT00623415.
Effect of the Kv7-channel Opener Flupirtine on the Excitability of Human Peripheral Myelinated Axons in Vivo ClinicalTrials.gov, 12 Oct 2011 Accessed on 14 Feb 2012 from http://clinicaltrials.gov/ct2/show/NCT01450865.
Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltage independent potassium channels. Rapid communication. Kornhuber J, Bleich S, Wiltfang J, Maler M, Parsons CG J Neural Transm. 1999; 106(9-10):857-67. PMID: 10599868. Abstract
[Reduction of spastic increased muscle tone in multiple sclerosis by the nonopioid analgesic flupirtine]. Göbel H, Schmid J, Heinze A, Pergande G Schmerz. 1999 Oct 15; 13(5):324-31. PMID: 12799920. Abstract
Activation of axonal Kv7 channels in human peripheral nerve by flupirtine but not placebo - therapeutic potential for peripheral neuropathies: results of a randomised controlled trial. Fleckenstein J, Sittl R, Averbeck B, Lang PM, Irnich D, Carr RW J Transl Med. 2013; 11:34. Epub 2013 Feb 08. PMID: 23394517. Abstract