Minocycline chelates Ca2+, binds to membranes, and depolarizes mitochondria by formation of Ca2+-dependent ion channels.

Antonenko YN, Rokitskaya TI, Cooper AJL, Krasnikov BF

J Bioenerg Biomembr. 2010 Apr; 42(2):151-63. Epub 2010 Feb 24. PMID: 20180001. Abstract