Cortical demyelination can be modeled in specific rat models of autoimmune encephalomyelitis and is major histocompatibility complex (MHC) haplotype-related.

Storch MK, Bauer J, Linington C, Olsson T, Weissert R, Lassmann H

J Neuropathol Exp Neurol. 2006 Dec; 65(12):1137-42. PMID: 17146287. Abstract