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Refined Animal Model Led to Phenytoin Clinical Trial

Katie Lidster
In 2010, Professor David Baker was awarded an NC3Rs Project Grant to develop a...
An animal model that presents an alternative to EAE suggested a role for sodium channel blockers in neuroprotection. This led directly to a successful human trial of phenytoin, which was presented at last week’s AAN meeting.
Clinical Research, Drug Development, Laboratory Research, Meetings, Methods

Seeking Answers for Progressive MS

International Progressive MS Alliance logo
An invitational meeting in Boston marks a step forward in a concerted international push to find effective therapies to target disease mechanisms, manage symptoms, and improve rehabilitation
A meeting in Boston early in March drew more than 80 scientists and clinical researchers to address...
Clinical Research, Drug Development, Laboratory Research, Meetings

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Clinical Research, Drug Development, Laboratory Research, Meetings, Methods, People

“Long Life” Protein Klotho Powers Remyelination in Mice

Clotho
Klotho is known to play a role in a number of age-related diseases, such as Alzheimer’s. New research suggests that a small molecule that boosts production of this protein may enhance maturation of OPCs into myelin-producing cells.
According to Greek myth, Clotho was the youngest of the three Morai, the trio of fates responsible for...
Laboratory Research, Meetings

The Paradox of Daclizumab

Dr. Bibiana Bielekova
Phase 3 results show that daclizumab reduces disease activity in relapsing-remitting multiple sclerosis by half compared with interferon, as measured by brain imaging, with skin and other side effects. The drug works in surprising ways that are revealing new details about the pathogenesis of MS.
Three might be the lucky number for daclizumab, an investigational drug for relapsing-remitting multiple sclerosis with...
Clinical Research, Drug Development, Laboratory Research, Meetings

ACTRIMS-ECTRIMS 2014 -- Day 4

The meeting's final day featured late breakers, the closing lecture, and two masterful summaries of research highlights
Last day of #ACTRIMS #ECTRIMS 2day! L8 breaking news & closing plenary-awards...
Clinical Research, Drug Development, Laboratory Research, Meetings, Methods, People

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