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Laboratory Research

Kir4.1 Potassium Channels in MS: Discrepant Results From Two Studies

Birth of an idea
Two teams of researchers found strikingly different degrees of autoimmune response to Kir4.1 inward rectifying potassium channels among multiple sclerosis patients. At first, the reason for the discrepancy wasn’t obvious.
When experimental findings disagree, or demonstrate very different strengths of an association, several explanations are...
Clinical Research, Laboratory Research

Make Way for Another MS Model?

Mouse models comparison
In a head-to-head comparison of four MS models, one based on HSV-1 infection shows its value
It’s caused plenty of embarrassment, but the virus that triggers cold sores could also provide insight into...
Clinical Research, Drug Development, Laboratory Research, Meetings, Methods, People

Decoding Brain Disease

Orion wanted poster
Computer analyses extract new insights from MS patient data
Since he was diagnosed with multiple sclerosis in 2007, Curtis Schreiner, a three-time U.S. Olympian in the biathlon, has...
Clinical Research, Drug Development, Laboratory Research, Meetings, Methods, People

MS Research Roundup: April 18, 2014

Research Roundup logo
Progress Toward New MS Clinical Trial Outcomes; Adaptive Design Evolves; A Call for Fundamental Neuroscience Research; MS Miracle Cures
Items of interest to multiple sclerosis researchers from around the Web...
Clinical Research, Drug Development, Laboratory Research, People

Myelin and Axons Don’t Form a Perfect, Uniform Union

Pyramidal neurons 3D
New findings from mice may rewrite our understanding of just about everything myelin-related. Outside experts describe the study as “landmark,” “novel,” “unexpected,” “new,” “important,” “surprising,” “stunning,” and “provocative.”
Myelin, the fatty insulation that boosts nerve signal conduction, might not be the ubiquitous...
Laboratory Research

Explaining Fingolimod’s Fatal Flaw

Fingolimod
The unphosphorylated, “inactive” version of fingolimod may be responsible for one of the drug’s most serious downsides: susceptibility to viral infections
Because it’s a pill, fingolimod spares MS patients from shots, but it also boosts the risk of...
Laboratory Research

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