Episode 45 with Dr. Simon Hametner on the role of iron in MS
Links to articles and other resources mentioned in Episode 45
Methods
Episode 44 with Dr. Monika Bradl on an animal model for neuromyelitis optica (NMO)
Links to articles and other resources mentioned in Episode 44
Methods
Episode 43 with Dr. May Han on following patients through the course of their disease
Links to articles and other resources mentioned in Episode 43
Methods
Gene Variant Associated with Non-Response to Interferon β
A variant of a gene called SLC9A9 appears significantly more often in people with MS who fail to respond to interferon β therapy
A variant of a gene called SLC9A9 appears significantly more often in people with MS who fail to respond to interferon β therapy
In a meta-analysis involving three independent cohorts of patients, researchers have identified a...
Clinical Research
Episode 42 with Dr. Lawrence Steinman on amyloid in experimental autoimmune encephalomyelitis
Links to articles and other resources mentioned in Episode 42
Methods
Time to Rethink CIS Criteria
About 20% of patients do not meet the diagnostic criteria of clinically isolated syndrome (CIS) based on radiological and clinical evidence. Patients who do not fit the CIS diagnostic criteria may yet have oligoclonal bands distinct to CSF, increased IgG synthesis rate and IgG index and must be treated as if they carried a diagnosis of CIS.
About 20% of patients do not meet the diagnostic criteria of clinically isolated syndrome (CIS) based on radiological and clinical evidence. Patients who do not fit the CIS diagnostic criteria may yet have oligoclonal bands distinct to CSF, increased IgG synthesis rate and IgG index and must be treated as if they carried a diagnosis of CIS.
It’s time to rethink the diagnostic criteria for clinically isolated syndrome. CIS is defined as...
Methods, People
Episode 41 with Dr. Diego Cadavid on a clinical trial of anti-LINGO-1
Links to articles and other resources mentioned in Episode 41
Methods
Episode 40 with Dr. Raj Kapoor on a clinical trial of phenytoin
Links to articles and other resources mentioned in Episode 40
Methods
Refined Animal Model Led to Phenytoin Clinical Trial
An animal model that presents an alternative to EAE suggested a role for sodium channel blockers in neuroprotection. This led directly to a successful human trial of phenytoin, which was presented at last week’s AAN meeting.
An animal model that presents an alternative to EAE suggested a role for sodium channel blockers in neuroprotection. This led directly to a successful human trial of phenytoin, which was presented at last week’s AAN meeting.
In 2010, Professor David Baker was awarded an NC3Rs Project Grant to develop a...
Clinical Research, Drug Development, Laboratory Research, Meetings, Methods
Episode 39 with Dr. Joseph Berger on diagnostic dilemmas in MS
Links to articles and other resources mentioned in Episode 39
Methods