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MS Trial Alert: Researchers in California, Colorado, New Mexico and Pennsylvania Recruiting Women with Progressive or Relapsing MS for Study of Estriol to Improve Cognition

May 8, 2014
 
Summary: Investigators in California, Colorado, New Mexico and Pennsylvania are recruiting 64 women with MS relapsing-remitting, secondary-progressive, or primary-progressive for a 12-month study in which the sex hormone estriol will be compared with inactive placebo for effects on cognitive function. Participants can remain on their prescribed MS medication throughout the study. Rhonda Voskuhl, MD (University of California at Los Angeles) is the principal investigator of the trial.

Low-Dose Naltrexone and Met-Enkephalin Improve EAE Mice

Naltrexone
Widely touted in multiple sclerosis patient communities, low-dose naltrexone does appear to improve disease scores in about half of mice with an experimentally induced version of MS. Researchers found a similar pattern of results with met-enkephalin.
A growing subculture of MS patients and clinicians has been touting low-dose...
Clinical Research, Drug Development, Laboratory Research, Meetings

Kir4.1 Potassium Channels in MS: Discrepant Results From Two Studies

Birth of an idea
Two teams of researchers found strikingly different degrees of autoimmune response to Kir4.1 inward rectifying potassium channels among multiple sclerosis patients. At first, the reason for the discrepancy wasn’t obvious.
When experimental findings disagree, or demonstrate very different strengths of an association, several explanations are...
Clinical Research, Laboratory Research

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