Rocky Mountain MS Center Tissue Bank
Sponsoring organization
Rocky Mountain MS Center
Repository website
http://www.mscenter.org/research/tissue-bank/
Primary contact
Nina Wells
PRA-Clinical Research Coordinator
Rocky Mountain MS Center at Anschutz Medical Center
University of Colorado, Department of Neurology
12631 E. 17th Ave, Room 5506, Mail Stop B185
Aurora, CO 80045
Tel 1-303-724-6247
Fax 1-303-724-0985
Sample types available
Postmortem brain tissue
Postmortem spinal cord
Postmortem cerebrospinal fluid
Postmortem serum
Sample-processing information
Depending on the distance from the site, there are two different processes a brain can undergo. In general, out-of-state brains are stored in formalin and kept as whole-brain sections that can be used for processes such as neuroimaging. In-state brains undergo plaque picking before being processed using snap-frozen or slow-frozen techniques. Each individual brain undergoes the same process.
Data available for each sample
Clinical records and pathology are available if researcher signs a limited data set agreement (all identifying information is blacked out).
RMMSC also collects information on whether the subject has participated in the ACP repository or the NARCOMS Registry.
Quantity of available samples
Currently over 340 brains – mostly MS but also a few controls.
Who can request samples
Researchers who are not affiliated with for-profit companies, except if they are working on a collaborative project with the RMMSC.
Cost
The only cost for academic requests is the sample shipping cost.
How to request samples
Fill out tissue request form and return to the Rocky Mountain MS Center Tissue Bank for approval.
http://www.mscenter.org/images/stories/Tissue_request_form_9_2.doc
Requirements associated with sample use
In publications, the investigator must acknowledge the RMMSC and the NMSS.
Ongoing sample collection?
Yes.
Sample Publications
Haplotypes within genes of beta-chemokines in 17q11 are associated with multiple sclerosis: a second phase study.
Vyshkina T, Kalman B.
Hum. Genet. 2005 Oct;118(1):67-75. PMID: 16078049
Haplotypes within genes of beta-chemokines in 17q11 are associated with multiple sclerosis: a second phase study.
Vyshkina T, Kalman B.
Hum. Genet. 2005 Oct;118(1):67-75. PMID: 16078049
Involvement of beta-chemokines in the development of inflammatory demyelination.
Banisor I, Leist TP, Kalman B.
J. Neuroinflammation. 2005 Feb 24;2(1):7. PMID: 15730561
Genetic variants of Complex I in multiple sclerosis.
Vyshkina T, Banisor I, Shugart YY, Leist TP, Kalman B.
J. Neurol. Sci. 2005 Jan 15;228(1):55-64. PMID: 15607211
CD45 (PTPRC) as a candidate gene in multiple sclerosis.
Vyshkina T, Leist TP, Shugart YY, Kalman B.
Mult Scler. 2004 Dec;10(6):614-7. PMID: 15584483
Association of haplotypes in the beta-chemokine locus with multiple sclerosis.
Vyshkina T, Shugart YY, Birnbaum G, Leist TP, Kalman B.
Eur J Hum Genet. 2005 Feb;13(2):240-7. PMID: 15494740
Familial multiple sclerosis and other inherited disorders of the white matter.
Kalman B, Leist TP.
Neurologist. 2004 Jul;10(4):201-15. PMID: 15245586
Evidence of nitrosative damage in the brain white matter of patients with multiple sclerosis.
Bizzozero OA, DeJesus G, Bixler HA, Pastuszyn A.
Neurochem Res. 2005 Jan;30(1):139-49. PMID: 15756942
Elevated protein carbonylation in the brain white matter and gray matter of patients with multiple sclerosis.
Bizzozero OA, DeJesus G, Callahan K, Pastuszyn A.
J Neurosci Res. 2005 Sep 1;81(5):687-95. PMID: 16007681
Detection of chlamydial bodies and antigens in the central nervous system of patients with multiple sclerosis.
Sriram S, Ljunggren-Rose A, Yao SY, Whetsell WO Jr.
J Infect Dis. 2005 Oct 1;192(7):1219-28. PMID: 16136465
Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia.
Li Y, Chu N, Hu A, Gran B, Rostami A, Zhang GX.
Brain. 2007 Feb;130(Pt 2):490-501.
Lack of mitochondrial DNA deletions in lesions of multiple sclerosis.
Blokhin A, Vyshkina T, Komoly S, Kalman B.
Neuromolec Med. 2008;10:187-94. PMID: 18286391
Variations in mitochondrial DNA copy numbers in MS brains.
Blokhin A, Vyshkina T, Komoly S, Kalman B.
J. Mol. Neurosci. 2008;35:283-7. PMID: 18566918
Oxidized phosphatidylcholine (OxPC) is a marker for neurodegeneration multiple sclerosis brain.
Qin J, Goswami R, Balabanov R, Dawson G.
J. Neurosci. Res. 2007;85:977-984.
Expression of the receptor for advanced glycation end products in oligodendrocytes in response to oxidative stress.
Qin J, Goswami R, Dawson S, Dawson G.
J. Neurosci. Res. 2008;86:2414-2422
A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis.
Wheeler D, Venkata V, Bandaru R, Calabresi PA, et al.
Brain. 2008 Nov;131(Pt 11):3092-102. PMID: 18772223