The UK Multiple Sclerosis Tissue Bank
Sponsoring organization
Centre for Neuroscience,
Imperial College London, Hammersmith Hospital Campus
Note: The UK Multiple Sclerosis Tissue Bank is a member of BrainNet Europe.
Tissue repository website
http://www.ukmstissuebank.imperial.ac.uk
Primary contact
Professor Richard Reynolds
The UK Multiple Sclerosis Tissue Bank
Centre for Neuroscience
Imperial College London
Hammersmith Hospital Campus
Du Cane Road
London W12 0NN
Tel 020-7594-6668
Fax 020-7594-9735
Sample types available
Postmortem central nervous system tissue from more than 450 clinically and neuropathologically well-documented multiple sclerosis (MS) cases, and from normal control subjects.
Sample-processing information
Cryopreserved brain and spinal cord tissue both fixed and unfixed, and cerebrospinal fluid. Freshly dissected tissue samples or those preserved using unconventional techniques may also be made available by prior arrangement.
Data available for each sample
A full clinical history and diagnostic neuropathology report is available for each case.
Quantity of available samples
More than 450 MS cases.
Who can request samples
Samples are available to “scientists investigating the pathogenesis of multiple sclerosis and related neuroinflammatory disorders.” The Tissue Bank operates an open-access policy to tissue and welcomes applications from academic, private- and public-sector researchers.
Cost
The researcher pays for shipping costs.
How to request samples
Complete the request form (http://www.ukmstissuebank.imperial.ac.uk/msreqpdf.pdf).
Sign and send to Professor Richard Reynolds (Scientific Director)
The UK Multiple Sclerosis Tissue Bank
Centre for Neuroscience
Imperial College London
Hammersmith Hospital Campus
Du Cane Road
London W12 0NN
The submitted form will be checked for accuracy by the Tissue Bank manager and passed on to the Peer Review Panel for assessment and recommendation. Once approved, your request will be processed, depending on the amount of work, within 1 to 3 calendar months.
Requirements associated with sample use
Tissue samples may not be passed on to a third party. A yearly report of the results obtained from use of the tissue must be sent to the tissue bank.
Ongoing sample collection?
Yes.
Sample Publications
Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis.
Howell OW, Reeves CA, Carassiti D, Nicholas R, Radotra B, Gentleman S, Roncaroli F, Gveric D, Serafini B, Aloisi A, Magliozzi R, Reynolds R (2011).
Brain 134:2755-2771.
The neuropathological basis of clinical progression in multiple sclerosis.
Reynolds R, Roncaroli F, Nicholas R, Radotra B, Gveric D, Howell O (2011).
Acta Neuropathol. 122:155-170.
A network of B-cells populates the meninges and parenchyma of patients with MS.
Lovato L, Willis SN, Rodig SJ, Caron T, Almendinger S, Howell O, Reynolds R, O’Connor KC, Hafler DA (2011).
Brain 134:534-541.
A gradient of neuronal loss and meningeal inflammation in multiple sclerosis.
Magliozzi R, Howell OW, Reeves C, Roncaroli F, Nicholas R, Serafini B, Aloisi F, Reynolds R (2010).
Ann. Neurol. 68:477-493.
Dysregulated Epstein-Barr virus infection on the multiple sclerosis brain.
Serafini B, Rosicarelli B, Franciotta D, Magliozzi R, Reynolds R, Conque P, Andreoni L, Trivedi P, Salvetti M, Faggioni A, Aloisi F (2007).
J. Exp. Med. 204:2899-2912.
High field (9.4 Tesla) magnetic resonance imaging of cortical grey matter lesions in multiple sclerosis.
Schmierer K, Parkes HG, So P-W, An SF, Brandner S, Ordidge R, Yousry TA, Miller DH (2010).
Brain 133:858-867.
Clinico-pathological evidence that axon loss underlies disability in progressive MS.
Tallantyre EC, Bo L, Al-Rawashdeh O, Owens T, Polman CH, Lowe JS, Evangelou N (2010).
Multiple Sclerosis 16:406-411.