Papers: 19 Sep 2014 - 26 Sep 2014 Check out this week's papers from PubMed. If you are a member, please log in to recommend and comment on papers. If you are not a member, please register today and join the conversation. Papers: A type 2 biomarker separates relapsing-remitting from secondary progressive multiple sclerosis. Dickens AM, Larkin JR, Griffin JL, Cavey A, Matthews L, Turner MR, Wilcock GK, Davis BG, Claridge TDW, Palace J, et al. Neurology. 2014 Sep 24. PMID: 25253748. Abstract Dysregulation of the IL-23/IL-17 axis and myeloid factors in secondary progressive MS. Huber AK, Wang L, Han P, Zhang X, Ekholm S, Srinivasan A, Irani DN, Segal BM Neurology. 2014 Sep 24. PMID: 25253754. Abstract Metabotropic glutamate receptor 5 modulates calcium oscillation and innate immune response induced by lipopolysaccharide in microglial cell. Liu F, Zhou R, Yan H, Yin H, Wu X, Tan Y, Li L Neuroscience. 2014 Sep 22. PMID: 25250840. Abstract The real-life experience with cardiovascular complications in the first dose of fingolimod for multiple sclerosis. Fragoso Y D, Arruda C C, Arruda W O, Brooks J B B, Damasceno A, de Damasceno C A A, Finkelsztejn A, Finkelsztejn J, da Gama P D, Giacomo M C B, et al. Arq Neuropsiquiatr. 2014 Sep; 72(9):712-4. PMID: 25252236. Abstract Myelin basic protein induces neuron-specific toxicity by directly damaging the neuronal plasma membrane. Zhang J, Sun X, Zheng S, Liu X, Jin J, Ren Y, Luo J PLoS One. 2014; 9(9):e108646. Epub 2014 Sep 25. PMID: 25255088. Abstract Falls in people with multiple sclerosis compared with falls in healthy controls. Mazumder R, Murchison C, Bourdette D, Cameron M PLoS One. 2014; 9(9):e107620. Epub 2014 Sep 25. PMID: 25254633. Abstract Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood-brain barrier under physiologic and neuroinflammatory conditions. Rom S, Zuluaga-Ramirez V, Dykstra H, Reichenbach NL, Ramirez SH, Persidsky Y J Cereb Blood Flow Metab. 2014 Sep 24. PMID: 25248836. Abstract Oral fingolimod to treat multiple sclerosis: see your cardiologist first. Sato D K, Callegaro D Arq Neuropsiquiatr. 2014 Sep; 72(9):651-2. PMID: 25252227. Abstract Combined EPR and Molecular Modeling Study of PPI Dendrimers Interacting with Copper Ions: Effect of Generation and Maltose Decoration. Furlan S, La Penna G, Appelhans D, Cangiotti M, Ottaviani M F, Danani A J Phys Chem B. 2014 Sep 23. PMID: 25247928. Abstract Default Network Connectivity Is Linked to Memory Status in Multiple Sclerosis. Leavitt VM, Paxton J, Sumowski JF J Int Neuropsychol Soc. 2014 Sep 23:1-8. PMID: 25248054. Abstract Transient gadolinium leakage in natalizumab-treated multiple sclerosis. Haller S, Barkhof F, Wattjes MP, Lalive PH J Neurol Neurosurg Psychiatry. 2014 Sep 22. PMID: 25246642. Abstract Review of the novelties presented at the 29th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (II). Fernandez O, Alvarez-Cermeno JC, Arnal-Garcia C, Arroyo-Gonzalez R, Brieva L, Calles-Hernandez MC, Casanova-Estruch B, Comabella M, Garcia-Merino JA, Izquierdo G, et al. Rev Neurol. 2014 Oct 1; 59(7):307-316. PMID: 25245875. Abstract Promoting remyelination: utilizing a viral model of demyelination to assess cell-based therapies. Marro BS, Blanc CA, Loring JF, Cahalan MD, Lane TE Expert Rev Neurother. 2014 Oct; 14(10):1169-79. PMID: 25245576. Abstract Recurrence of disease activity after repeated Natalizumab withdrawals. Ferrè L, Moiola L, Sangalli F, Radaelli M, Barcella V, Comi G, Martinelli V Neurol Sci. 2014 Sep 24. Epub 2014 Sep 24. PMID: 25249399. Abstract Discerning primary and secondary factors responsible for clinical fatigue in multisystem diseases. Maughan D, Toth M Biology (Basel). 2014; 3(3):606-22. PMID: 25247274. Abstract The influence of age and illness duration on cognitive impairment in aging patients with relapsing-remitting multiple sclerosis (RR-MS). Leclercq E, Cabaret M, Guilbert A, Jougleux C, Vermersch P, Moroni C Geriatr Psychol Neuropsychiatr Vieil. 2014 Sep 1; 12(3):331-338. PMID: 25245320. Abstract Outcomes After Early Administration of Plasma Exchange in Pediatric Central Nervous System Inflammatory Demyelination. Bigi S, Banwell B, Yeh AE J Child Neurol. 2014 Sep 22. PMID: 25246301. Abstract The experimental autoimmune encephalomyelitis disease course is modulated by nicotine and other cigarette smoke components. Gao Z, Nissen JC, Ji K, Tsirka SE PLoS One. 2014; 9(9):e107979. Epub 2014 Sep 24. PMID: 25250777. Abstract Uric acid: a potential biomarker of multiple sclerosis and of its disability. Moccia M, Lanzillo R, Palladino R, Russo C, Carotenuto A, Massarelli M, Vacca G, Vacchiano V, Nardone A, Triassi M, et al. Clin Chem Lab Med. 2014 Sep 20. PMID: 25241733. Abstract High CD6 and low chemokine receptor expression on peripheral blood lymphocytes correlates with MRI gadolinium enhancement in MS. Jurewicz A, Zaleski K, Domowicz M, Selmaj K J Neuroimmunol. 2014 Aug 27. PMID: 25242631. Abstract [A review of multiple sclerosis (1). Presentation of a case.] Martinez-Altarriba MC, Ramos-Campoy O, Luna-Calcaño IM, Arrieta-Antón E Semergen. 2014 Sep 17. PMID: 25241121. Abstract Correction: Intrathecal Infusion of Hydrogen-Rich Normal Saline Attenuates Neuropathic Pain via Inhibition of Activation of Spinal Astrocytes and Microglia in Rats. PLOS ONE Staff PLoS One. 2014; 9(9):e109482. Epub 2014 Sep 23. PMID: 25248156. Abstract The meninges: new therapeutic targets for multiple sclerosis. Russi AE, Brown MA Transl Res. 2014 Sep 1. PMID: 25241937. Abstract Protein 4.1R attenuates autoreactivity in experimental autoimmune encephalomyelitis by suppressing CD4(+) T cell activation. Liu X, Zhou Q, Ji Z, Fu G, Li Y, Zhang X, Shi X, Wang T, Kang Q Cell Immunol. 2014 Aug 27; 292(1-2):19-24. PMID: 25243644. Abstract Update on multiple sclerosis treatments. Bridel C, Lalive PH Swiss Med Wkly. 2014; 144:w14012. Epub 2014 Sep 23. PMID: 25247669. Abstract Correction: A Novel MicroRNA-132-Surtuin-1 Axis Underlies Aberrant B-cell Cytokine Regulation in Patients with Relapsing-Remitting Multiple Sclerosis. PLOS ONE Staff PLoS One. 2014; 9(9):e109041. Epub 2014 Sep 23. PMID: 25247999. Abstract Characterization of Oligodendroglial Populations in Mouse Demyelinating Disease Using Flow Cytometry: Clues for MS Pathogenesis. Robinson AP, Rodgers JM, Goings GE, Miller SD PLoS One. 2014; 9(9):e107649. Epub 2014 Sep 23. PMID: 25247590. Abstract The blood-brain barrier-permeable catechol-O-methyltransferase inhibitor dinitrocatechol suppresses experimental autoimmune encephalomyelitis. Polak PE, Lin S X, Pelligrino D, Feinstein DL J Neuroimmunol. 2014 Sep 16. PMID: 25242632. Abstract Seminal vesicle fluid ameliorates experimental autoimmune encephalomyelitis by increasing FoxP3(+) regulatory T-cell numbers. Pakravan N, Ghaffarinia A, Jalili C, Riazi-Rad F, Tajedini M, Mostafaie A Cell Mol Immunol. 2014 Sep 22. PMID: 25242273. Abstract Functional cerebral changes in multiple sclerosis patients during an autobiographical memory test. Ernst A, Noblet V, Denkova E, Blanc F, de Seze J, Gounot D, Manning L Memory. 2014 Sep 22:1-17. PMID: 25244436. Abstract How do we manage and treat a patient with multiple sclerosis at risk of tuberculosis? Fragoso Y D, Adoni T, Anacleto A, Brooks J B B, de Carvalho M J, Claudino R, Damasceno A, Ferreira M L B, da Gama P D, Goncalves M V M, et al. Expert Rev Neurother. 2014 Sep 22:1-10. PMID: 25242167. Abstract Age-related Shift in Neural Complexity Related to Task Performance and Physical Activity. Heisz JJ, Gould M, McIntosh AR J Cogn Neurosci. 2014 Sep 22:1-9. PMID: 25244121. Abstract Efficacy and Safety of Fingolimod in Hispanic Patients with Multiple Sclerosis: Pooled Clinical Trial Analyses. Chinea Martinez AR, Correale J, Coyle PK, Meng X, Tenenbaum N Adv Ther. 2014 Sep 23. Epub 2014 Sep 23. PMID: 25245812. Abstract Onion-shaped white matter disease? Spaander FHM, Vink T, Natté R, de Bruijn SFTM Clin Neurol Neurosurg. 2014 Sep 16; 126C:123-125. PMID: 25243974. Abstract Microparticles in multiple sclerosis and clinically isolated syndrome: effect on endothelial barrier function. Marcos-Ramiro B, Oliva Nacarino P, Serrano-Pertierra E, Blanco-Gelaz M A, Weksler BB, Romero IA, Couraud PO, Tuñón A, López-Larrea C, Millán J, et al. BMC Neurosci. 2014; 15(1):110. Epub 2014 Sep 22. PMID: 25242463. Abstract Cholinergic System Dysfunction and Neurodegenerative Diseases: Cause or Effect? Tata AM, Velluto L, D'Angelo C, Reale M CNS Neurol Disord Drug Targets. 2014 Sep 17. PMID: 25230223. Abstract Evaluation of hemodynamic properties of cerebral venous drainage in patients with multiple sclerosis: a case-control study. Jandaghi A B, Amanian D, Roudbari S A, Kanafi A R, Pourghorban R Pol J Radiol. 2014; 79:323-7. Epub 2014 Sep 19. PMID: 25250100. Abstract Novel somatic single nucleotide variants within the RNA binding protein hnRNP A1 in multiple sclerosis patients. Lee S, Levin M F1000Res. 2014; 3:132. Epub 2014 Sep 18. PMID: 25254102. Abstract Association between smoking and cognitive impairment in multiple sclerosis. Ozcan M E, Ince B, Bingöl A, Ertürk S, Altınöz M A, Karadeli H H, Koçer A, Asil T Neuropsychiatr Dis Treat. 2014; 10:1715-9. Epub 2014 Sep 10. PMID: 25246792. Abstract Interleukin-17 in human inflammatory diseases. Shabgah A G, Fattahi E, Shahneh F Z Postepy Dermatol Alergol. 2014 Aug; 31(4):256-61. Epub 2014 Sep 08. PMID: 25254011. Abstract Perceived cognitive decline in multiple sclerosis impacts quality of life independently of depression. Samartzis L, Gavala E, Zoukos Y, Aspiotis A, Thomaides T Rehabil Res Pract. 2014; 2014:128751. Epub 2014 Sep 01. PMID: 25254118. Abstract Efficient generation of myelinating oligodendrocytes from primary progressive multiple sclerosis patients by induced pluripotent stem cells. Douvaras P, Wang J, Zimmer M, Hanchuk S, O'Bara MA, Sadiq S, Sim FJ, Goldman J, Fossati V Stem Cell Reports. 2014 Aug 12; 3(2):250-9. Epub 2014 Jul 24. PMID: 25254339. Abstract
A type 2 biomarker separates relapsing-remitting from secondary progressive multiple sclerosis. Dickens AM, Larkin JR, Griffin JL, Cavey A, Matthews L, Turner MR, Wilcock GK, Davis BG, Claridge TDW, Palace J, et al. Neurology. 2014 Sep 24. PMID: 25253748. Abstract
Dysregulation of the IL-23/IL-17 axis and myeloid factors in secondary progressive MS. Huber AK, Wang L, Han P, Zhang X, Ekholm S, Srinivasan A, Irani DN, Segal BM Neurology. 2014 Sep 24. PMID: 25253754. Abstract
Metabotropic glutamate receptor 5 modulates calcium oscillation and innate immune response induced by lipopolysaccharide in microglial cell. Liu F, Zhou R, Yan H, Yin H, Wu X, Tan Y, Li L Neuroscience. 2014 Sep 22. PMID: 25250840. Abstract
The real-life experience with cardiovascular complications in the first dose of fingolimod for multiple sclerosis. Fragoso Y D, Arruda C C, Arruda W O, Brooks J B B, Damasceno A, de Damasceno C A A, Finkelsztejn A, Finkelsztejn J, da Gama P D, Giacomo M C B, et al. Arq Neuropsiquiatr. 2014 Sep; 72(9):712-4. PMID: 25252236. Abstract
Myelin basic protein induces neuron-specific toxicity by directly damaging the neuronal plasma membrane. Zhang J, Sun X, Zheng S, Liu X, Jin J, Ren Y, Luo J PLoS One. 2014; 9(9):e108646. Epub 2014 Sep 25. PMID: 25255088. Abstract
Falls in people with multiple sclerosis compared with falls in healthy controls. Mazumder R, Murchison C, Bourdette D, Cameron M PLoS One. 2014; 9(9):e107620. Epub 2014 Sep 25. PMID: 25254633. Abstract
Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood-brain barrier under physiologic and neuroinflammatory conditions. Rom S, Zuluaga-Ramirez V, Dykstra H, Reichenbach NL, Ramirez SH, Persidsky Y J Cereb Blood Flow Metab. 2014 Sep 24. PMID: 25248836. Abstract
Oral fingolimod to treat multiple sclerosis: see your cardiologist first. Sato D K, Callegaro D Arq Neuropsiquiatr. 2014 Sep; 72(9):651-2. PMID: 25252227. Abstract
Combined EPR and Molecular Modeling Study of PPI Dendrimers Interacting with Copper Ions: Effect of Generation and Maltose Decoration. Furlan S, La Penna G, Appelhans D, Cangiotti M, Ottaviani M F, Danani A J Phys Chem B. 2014 Sep 23. PMID: 25247928. Abstract
Default Network Connectivity Is Linked to Memory Status in Multiple Sclerosis. Leavitt VM, Paxton J, Sumowski JF J Int Neuropsychol Soc. 2014 Sep 23:1-8. PMID: 25248054. Abstract
Transient gadolinium leakage in natalizumab-treated multiple sclerosis. Haller S, Barkhof F, Wattjes MP, Lalive PH J Neurol Neurosurg Psychiatry. 2014 Sep 22. PMID: 25246642. Abstract
Review of the novelties presented at the 29th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (II). Fernandez O, Alvarez-Cermeno JC, Arnal-Garcia C, Arroyo-Gonzalez R, Brieva L, Calles-Hernandez MC, Casanova-Estruch B, Comabella M, Garcia-Merino JA, Izquierdo G, et al. Rev Neurol. 2014 Oct 1; 59(7):307-316. PMID: 25245875. Abstract
Promoting remyelination: utilizing a viral model of demyelination to assess cell-based therapies. Marro BS, Blanc CA, Loring JF, Cahalan MD, Lane TE Expert Rev Neurother. 2014 Oct; 14(10):1169-79. PMID: 25245576. Abstract
Recurrence of disease activity after repeated Natalizumab withdrawals. Ferrè L, Moiola L, Sangalli F, Radaelli M, Barcella V, Comi G, Martinelli V Neurol Sci. 2014 Sep 24. Epub 2014 Sep 24. PMID: 25249399. Abstract
Discerning primary and secondary factors responsible for clinical fatigue in multisystem diseases. Maughan D, Toth M Biology (Basel). 2014; 3(3):606-22. PMID: 25247274. Abstract
The influence of age and illness duration on cognitive impairment in aging patients with relapsing-remitting multiple sclerosis (RR-MS). Leclercq E, Cabaret M, Guilbert A, Jougleux C, Vermersch P, Moroni C Geriatr Psychol Neuropsychiatr Vieil. 2014 Sep 1; 12(3):331-338. PMID: 25245320. Abstract
Outcomes After Early Administration of Plasma Exchange in Pediatric Central Nervous System Inflammatory Demyelination. Bigi S, Banwell B, Yeh AE J Child Neurol. 2014 Sep 22. PMID: 25246301. Abstract
The experimental autoimmune encephalomyelitis disease course is modulated by nicotine and other cigarette smoke components. Gao Z, Nissen JC, Ji K, Tsirka SE PLoS One. 2014; 9(9):e107979. Epub 2014 Sep 24. PMID: 25250777. Abstract
Uric acid: a potential biomarker of multiple sclerosis and of its disability. Moccia M, Lanzillo R, Palladino R, Russo C, Carotenuto A, Massarelli M, Vacca G, Vacchiano V, Nardone A, Triassi M, et al. Clin Chem Lab Med. 2014 Sep 20. PMID: 25241733. Abstract
High CD6 and low chemokine receptor expression on peripheral blood lymphocytes correlates with MRI gadolinium enhancement in MS. Jurewicz A, Zaleski K, Domowicz M, Selmaj K J Neuroimmunol. 2014 Aug 27. PMID: 25242631. Abstract
[A review of multiple sclerosis (1). Presentation of a case.] Martinez-Altarriba MC, Ramos-Campoy O, Luna-Calcaño IM, Arrieta-Antón E Semergen. 2014 Sep 17. PMID: 25241121. Abstract
Correction: Intrathecal Infusion of Hydrogen-Rich Normal Saline Attenuates Neuropathic Pain via Inhibition of Activation of Spinal Astrocytes and Microglia in Rats. PLOS ONE Staff PLoS One. 2014; 9(9):e109482. Epub 2014 Sep 23. PMID: 25248156. Abstract
The meninges: new therapeutic targets for multiple sclerosis. Russi AE, Brown MA Transl Res. 2014 Sep 1. PMID: 25241937. Abstract
Protein 4.1R attenuates autoreactivity in experimental autoimmune encephalomyelitis by suppressing CD4(+) T cell activation. Liu X, Zhou Q, Ji Z, Fu G, Li Y, Zhang X, Shi X, Wang T, Kang Q Cell Immunol. 2014 Aug 27; 292(1-2):19-24. PMID: 25243644. Abstract
Update on multiple sclerosis treatments. Bridel C, Lalive PH Swiss Med Wkly. 2014; 144:w14012. Epub 2014 Sep 23. PMID: 25247669. Abstract
Correction: A Novel MicroRNA-132-Surtuin-1 Axis Underlies Aberrant B-cell Cytokine Regulation in Patients with Relapsing-Remitting Multiple Sclerosis. PLOS ONE Staff PLoS One. 2014; 9(9):e109041. Epub 2014 Sep 23. PMID: 25247999. Abstract
Characterization of Oligodendroglial Populations in Mouse Demyelinating Disease Using Flow Cytometry: Clues for MS Pathogenesis. Robinson AP, Rodgers JM, Goings GE, Miller SD PLoS One. 2014; 9(9):e107649. Epub 2014 Sep 23. PMID: 25247590. Abstract
The blood-brain barrier-permeable catechol-O-methyltransferase inhibitor dinitrocatechol suppresses experimental autoimmune encephalomyelitis. Polak PE, Lin S X, Pelligrino D, Feinstein DL J Neuroimmunol. 2014 Sep 16. PMID: 25242632. Abstract
Seminal vesicle fluid ameliorates experimental autoimmune encephalomyelitis by increasing FoxP3(+) regulatory T-cell numbers. Pakravan N, Ghaffarinia A, Jalili C, Riazi-Rad F, Tajedini M, Mostafaie A Cell Mol Immunol. 2014 Sep 22. PMID: 25242273. Abstract
Functional cerebral changes in multiple sclerosis patients during an autobiographical memory test. Ernst A, Noblet V, Denkova E, Blanc F, de Seze J, Gounot D, Manning L Memory. 2014 Sep 22:1-17. PMID: 25244436. Abstract
How do we manage and treat a patient with multiple sclerosis at risk of tuberculosis? Fragoso Y D, Adoni T, Anacleto A, Brooks J B B, de Carvalho M J, Claudino R, Damasceno A, Ferreira M L B, da Gama P D, Goncalves M V M, et al. Expert Rev Neurother. 2014 Sep 22:1-10. PMID: 25242167. Abstract
Age-related Shift in Neural Complexity Related to Task Performance and Physical Activity. Heisz JJ, Gould M, McIntosh AR J Cogn Neurosci. 2014 Sep 22:1-9. PMID: 25244121. Abstract
Efficacy and Safety of Fingolimod in Hispanic Patients with Multiple Sclerosis: Pooled Clinical Trial Analyses. Chinea Martinez AR, Correale J, Coyle PK, Meng X, Tenenbaum N Adv Ther. 2014 Sep 23. Epub 2014 Sep 23. PMID: 25245812. Abstract
Onion-shaped white matter disease? Spaander FHM, Vink T, Natté R, de Bruijn SFTM Clin Neurol Neurosurg. 2014 Sep 16; 126C:123-125. PMID: 25243974. Abstract
Microparticles in multiple sclerosis and clinically isolated syndrome: effect on endothelial barrier function. Marcos-Ramiro B, Oliva Nacarino P, Serrano-Pertierra E, Blanco-Gelaz M A, Weksler BB, Romero IA, Couraud PO, Tuñón A, López-Larrea C, Millán J, et al. BMC Neurosci. 2014; 15(1):110. Epub 2014 Sep 22. PMID: 25242463. Abstract
Cholinergic System Dysfunction and Neurodegenerative Diseases: Cause or Effect? Tata AM, Velluto L, D'Angelo C, Reale M CNS Neurol Disord Drug Targets. 2014 Sep 17. PMID: 25230223. Abstract
Evaluation of hemodynamic properties of cerebral venous drainage in patients with multiple sclerosis: a case-control study. Jandaghi A B, Amanian D, Roudbari S A, Kanafi A R, Pourghorban R Pol J Radiol. 2014; 79:323-7. Epub 2014 Sep 19. PMID: 25250100. Abstract
Novel somatic single nucleotide variants within the RNA binding protein hnRNP A1 in multiple sclerosis patients. Lee S, Levin M F1000Res. 2014; 3:132. Epub 2014 Sep 18. PMID: 25254102. Abstract
Association between smoking and cognitive impairment in multiple sclerosis. Ozcan M E, Ince B, Bingöl A, Ertürk S, Altınöz M A, Karadeli H H, Koçer A, Asil T Neuropsychiatr Dis Treat. 2014; 10:1715-9. Epub 2014 Sep 10. PMID: 25246792. Abstract
Interleukin-17 in human inflammatory diseases. Shabgah A G, Fattahi E, Shahneh F Z Postepy Dermatol Alergol. 2014 Aug; 31(4):256-61. Epub 2014 Sep 08. PMID: 25254011. Abstract
Perceived cognitive decline in multiple sclerosis impacts quality of life independently of depression. Samartzis L, Gavala E, Zoukos Y, Aspiotis A, Thomaides T Rehabil Res Pract. 2014; 2014:128751. Epub 2014 Sep 01. PMID: 25254118. Abstract
Efficient generation of myelinating oligodendrocytes from primary progressive multiple sclerosis patients by induced pluripotent stem cells. Douvaras P, Wang J, Zimmer M, Hanchuk S, O'Bara MA, Sadiq S, Sim FJ, Goldman J, Fossati V Stem Cell Reports. 2014 Aug 12; 3(2):250-9. Epub 2014 Jul 24. PMID: 25254339. Abstract