Temporal relationship between elevation of epstein-barr virus antibody titers and initial onset of neurological symptoms in multiple sclerosis.
Levin LI, Munger KL, Rubertone MV, Peck CA, Lennette ET, Spiegelman D, Ascherio A
JAMA. 2005 May 25; 293(20):2496-500. PMID: 15914750.Abstract
Suggested by Robyn Lucas
The truly classic studies of a role for EBV in the risk of multiple sclerosis are those from the U.S. military cohort, even though they are quite recent. With the large study sample and blood taken on multiple occasions, the studies have allowed a comprehensive examination of the timing of EBV infection and development of MS. Findings on a time window from infection to MS onset, of 100% conversion to seropositivity before MS onset in those who were initially seronegative, and increases in EBV antibody titers in late adolescence in those who would go on to develop MS compared to healthy controls, are fascinating and provide a strong contribution to progress in this field of study.
Suggested by Robyn Lucas
The truly classic studies of a role for EBV in the risk of multiple sclerosis are those from the U.S. military cohort, even though they are quite recent. With the large study sample and blood taken on multiple occasions, the studies have allowed a comprehensive examination of the timing of EBV infection and development of MS. Findings on a time window from infection to MS onset, of 100% conversion to seropositivity before MS onset in those who were initially seronegative, and increases in EBV antibody titers in late adolescence in those who would go on to develop MS compared to healthy controls, are fascinating and provide a strong contribution to progress in this field of study.