New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC, Johnson KP, Sibley WA, Silberberg DH, Tourtellotte WW
Ann Neurol. 1983 Mar; 13(3):227-31. PMID: 6847134.Abstract
Suggested By Alastair Compston and alasdair coles
Poser’s motivation to introduce diagnostic criteria for multiple sclerosis was to improve research and in particular, the quality of epidemiological studies. Almost 2 decades earlier, he had derived a scoring system to refine the clinician’s suspicion of multiple sclerosis, but it was too complex and it never took off. So, Poser gathered the luminaries of multiple sclerosis, who proposed four categories of the disease: “clinically definite, laboratory-supported definite, clinically probable, and laboratory-supported probable.” At last “paraclinical” evidence of a lesion could be substituted for clinical evidence. Poser’s criteria lasted nearly 2 decades until it was replaced by the 2001 McDonald criteria, which were themselves modified in 2005 and, most recently, in 2010.
Suggested By Alastair Compston and alasdair coles
Poser’s motivation to introduce diagnostic criteria for multiple sclerosis was to improve research and in particular, the quality of epidemiological studies. Almost 2 decades earlier, he had derived a scoring system to refine the clinician’s suspicion of multiple sclerosis, but it was too complex and it never took off. So, Poser gathered the luminaries of multiple sclerosis, who proposed four categories of the disease: “clinically definite, laboratory-supported definite, clinically probable, and laboratory-supported probable.” At last “paraclinical” evidence of a lesion could be substituted for clinical evidence. Poser’s criteria lasted nearly 2 decades until it was replaced by the 2001 McDonald criteria, which were themselves modified in 2005 and, most recently, in 2010.