Icariin has synergistic effects with methylprednisolone to ameliorate EAE via modulating HPA function, promoting anti-inflammatory and anti-apoptotic effects.
Wei Z, Deng X, Hong M, Su Q, Liu A, Huang Y, Yu Q, Peng Z
Int J Clin Exp Med. 2015; 8(11):20188-97. Epub 2015 Nov 15. PMID: 26884931.Abstract